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FLASH GENE
Symbol SCG5 contributors: mct/npt - updated : 26-08-2014
HGNC name secretogranin V (7B2 protein)
HGNC id 10816
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal peptide that can inhibit PC2 and may contribute to keep the enzyme transiently inactive (Mbikay 2001)
    • HOMOLOGY
    interspecies homolog to rattus Sgne1
    ortholog to murine Sgne1
    homolog to Xenopus Xl.1105
    homolog to zebrafish Dr.12487
    homolog to C.elegans R07E3.7
    Homologene
    FAMILY
  • granin family of proteins
    • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text neuroendocrine and endocrine secretory granules
    basic FUNCTION
  • acting as a enzyme activator
  • acting as a specific chaperone for proprotein convertase-2 (PC2)
  • acidic protein residing in the secretory granules of neuroendocrine cells (Mbikay 2001)
  • regulator/activator of the prohormone convertase 2 which is involved in the processing of numerous neuropeptides, including insulin, glucagon and pro-opiomelanocortin
  • role for SCG5 in the modulation of body weight
  • PCSK2 requires interaction with the neuroendocrine protein SCG5 for the production of an activatable zymogen
  • can also act as a postfolding chaperone to block the aggregation of a number of other proteins, for example, SNCA
  • is a natively disordered protein whose function as an antiaggregant chaperone is likely facilitated by its lack of appreciable secondary structure and tendency to form oligomers
  • is a novel anti-aggregation secretory chaperone associated with neurodegenerative disease
  • likely playing a role in the etiology of aggregate formation in neurodegenerative disease
  • neuronal SCG5 could function to block neurodegenerative disease-related protein aggregation
  • SCG5 and PCSK1N may perform a chaperone role as secretory anti-aggregants in normal islet cell function and in type 2 diabetes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    neuropeptide signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
    • protein
  • required for the production of active prohormone convertase 2 (PCSK2), an enzyme involved in the synthesis of peptide hormones, such as glucagon and POMC
  • is a prohormone convertase 2 (PCSK2)-binding protein
  • it is possible that SCG5 acts via similar molecular mechanisms to decrease APP protein oligomerization, fibrillation, and cytotoxicity
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    silenced gene in medulloblastomas (Waha 2007)
    constitutional     --over  
    in brain tissues of AD patients, and in the cerebrospinal fluid of amyotrophic lateral sclerosis patients
    tumoral     --low  
    silenced by DNA methylation in astrocytic gliomas
    Susceptibility
  • to glucoise intolerance in obesity
  • to colorectal cancer (CRC)
    • Variant & Polymorphism SNP
  • SNP -1,701A>G did not associate with risk of T2D but tends to associate with incidence of type 2 diabetes (may worsen glucose intolerance and insulin resistance, especially in the background of severe and early onset obesity) (Bouatia-Naji 2007)
  • SNPs near SCG5 were strongly associated with increased CRC risk (Jaeger 2008)
    • Candidate gene good marker of several neuroendocrine cell dysfunctions (Mbikay 2001)
    Marker
    Therapy target
    ANIMAL & CELL MODELS