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FLASH GENE
Symbol ADK contributors: mct - updated : 16-10-2009
HGNC name adenosine kinase
HGNC id 257
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies homolog to murine Adk (91.4pc)
homolog to rattus Adk (90.3pc)
Homologene
FAMILY
  • carbohydrate kinase pfkB family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • regulator of concentration of both extracellular adenosine and intracellular adenine nucleotides
  • a critical role in modulating vascular adenosine responses (Morote-Garcia 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binding 3 magnesium ions Mg2+ per subunit
    • protein
    cell & other
    REGULATION
    repressed by HIF1 upon hypoxia, thus attenuating vascular leak (Morote-Garcia 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s) ADKD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    expression significantly higher in colorectal cancers (Giglioni 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    In homozygous Adk -/- mice, embryonic stem cells developed normally during embryogenesis. However, within 4 days after birth they displayed microvesicular hepatic steatosis and died within 14 days with fatty liver. Thus, a deficiency of adenosine metabolism is identified as a powerful contributor to the development of neonatal hepatic steatosis, providing a model for the rapid development of postnatally lethal fatty liver (Boison 2002)