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FLASH GENE
Symbol ADK contributors: mct - updated : 16-10-2009
HGNC name adenosine kinase
HGNC id 257
ANIMAL & CELL MODELS
In homozygous Adk -/- mice, embryonic stem cells developed normally during embryogenesis. However, within 4 days after birth they displayed microvesicular hepatic steatosis and died within 14 days with fatty liver. Thus, a deficiency of adenosine metabolism is identified as a powerful contributor to the development of neonatal hepatic steatosis, providing a model for the rapid development of postnatally lethal fatty liver (Boison 2002)