| Symbol
| AKT1
| contributors: mct - updated : 18-03-2019
|
| HGNC name
| v-akt murine thymoma viral oncogene homolog 1
|
| HGNC id
| 391
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
|
| gain of function
| |
amplified in gastric carcinoma | | tumoral
|
|
| --over
|
| |
in prostate, breast cancer | | constitutional
| somatic mutation
|
|
|
|
somatic activating mutation in Proteus syndrome  | | constitutional
| germinal mutation
|
|
| gain of function
| |
in Cowden and Cowden-like syndrome | | tumoral
|
| amplification
| --over
|
| |
in a defined subset of bone and soft tissue tumors, including benign tumors | | tumoral
|
| amplification
|
|
| |
amplification of AKT1 and/or AKT2 and high-level polysomy were found in lung carcinomas | |
| Susceptibility
|
to schizophrenia and bipolar disorders |
Variant & Polymorphism
SNP
| 
| |
Candidate gene
Marker
Therapy target
|
| | | |
|
| both Akt1-/- and Igf2-/- mice exhibited decreased placental weight, fetal weight and viability |