SUBCELLULAR LOCALIZATION
| plasma membrane,junction,adherens
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| intracellular
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| intracellular,cytoplasm,cytoskeleton
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text
| located at the cytoplasmic side of adhesion plaques (focal contact) |
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co-localizing with metaVCL to intercalated disc and costameres |
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cytoskeletal protein associated with focal adhesion and adherens junctions |
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localizes to focal adhesions and adherens junctions, connecting cell surface receptors to the actin cytoskeleton |
basic FUNCTION
| anchoring F actin to the plasma membrane |
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alphaE-catenin-vinculin interaction plays a role in the assembly of the apical junctional complex in epithelia |
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important in regulating adhesion dynamics and cell migration |
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controls focal adhesion formation by direct interactions with talin and actin (Humphries 2007) |
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involved in tightening of epithelial apical junctions during their maturation |
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plays an important role in cell adhesion and migration through interaction between vinculin and lipid membranes (Diez 2008) |
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involved in linking the actin cytoskeleton to the cell membrane at sites of cellular adhesion (Palmer 2009) |
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plays a role in physiological processes such as cell motility, migration, development, and wound healing (Palmer 2009) |
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facilitates phospholipid membrane insertion |
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protect junctions against overinduced opening by thrombin in remodeling focal adherens junctions |
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needed during active phases of junction remodeling by cytoskeletal force to protect junctions from opening |
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has pleiotropic roles in chondrocytic differentiation |
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tissue-specific function of VCL in cartilage whereby it controls chondrocytic differentiation |
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is a major component of the focal adhesion complex that acts as a mechano-coupler and an actin-binding protein |
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has pleiotropic roles in chondrogenesis and regulates the expression of chondrocyte-specific genes via the integration of various signaling pathways |
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VCL plays a key role in the transmission of extracellular mechanical stimuli leading to the reorganization of cell polarity |
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in cells, APBB1IP is enriched in nascent adhesions at the leading edge whereas VCL is enriched in focal adhesions (FAs) |
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major role for VCL in the control of the cytoskeletal connection affecting mechanical stability and cell motility |
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plays a key structural role in ventricular myocytes that, when disrupted, can lead to contractile dysfunction and dilated cardiomyopathy |
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VCL and TJP1 anchor the actin cytoskeleton to the sarcolemma |
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critical role of vinculin in mechanotransduction at adhesion sites |
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is an essential regulator of both adherens junctions (AJs) and focal adhesion (FA), where it provides links to the actin cytoskeleton |
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a plastic relationship between vinculin-mediated tension and adhesion complex area that controls fundamental cell-matrix adhesion properties |
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essential adhesion protein that links membrane-bound integrin and cadherin receptors through their intracellular binding partners to filamentous actin, facilitating mechanotransduction |
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actin-binding proteins TLN1 and VCL cooperate to provide the link between extracellular-matrix-bound integrins and intracellular F-actin, essential for cell spreading and migration |
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major regulator of cell adhesion and attaches to the cell surface by binding to specific phospholipids |