Citations for
Mechanisms and Functions of Vinculin Interactions with Phospholipids at Cell Adhesion Sites.
Izard T, Brown DT.
J Biol Chem 291(6):2548-55. doi: 10.1074/jbc.R115.686493. Epub 2016 Jan 4. Review. 2016
The Structural Basis of Actin Organization by Vinculin and Metavinculin.
Kim LY, Thompson PM, Lee HT, Pershad M, Campbell SL, Alushin GM.
J Mol Biol 428(1):10-25. doi: 10.1016/j.jmb.2015.09.031. Epub 2015 Oct 20. 2016
Vinculin controls talin engagement with the actomyosin machinery.
Atherton P, Stutchbury B, Wang DY, Jethwa D, Tsang R, Meiler-Rodriguez E, Wang P, Bate N, Zent R, Barsukov IL, Goult BT, Critchley DR, Ballestrem C.
Nat Commun 6:10038. doi: 10.1038/ncomms10038. 2015
A plastic relationship between vinculin-mediated tension and adhesion complex area defines adhesion size and lifetime.
Hernández-Varas P, Berge U, Lock JG, Strömblad S.
Nat Commun 6:7524. doi: 10.1038/ncomms8524. 2015
Vinculin-dependent actin bundling regulates cell migration and traction forces.
Jannie KM, Ellerbroek SM, Zhou DW, Chen S, Crompton DJ, García AJ, DeMali KA.
Biochem J 465(3):383-93. doi: 10.1042/BJ20140872. 2015
Lipid binding promotes oligomerization and focal adhesion activity of vinculin.
Chinthalapudi K, Rangarajan ES, Patil DN, George EM, Brown DT, Izard T.
J Cell Biol 207(5):643-56. doi: 10.1083/jcb.201404128. 2014
Identification of vinculin as a potential plasma marker for age-related macular degeneration.
Kim HJ, Woo SJ, Suh EJ, Ahn J, Park JH, Hong HK, Lee JE, Ahn SJ, Hwang DJ, Kim KW, Park KH, Lee C.
Invest Ophthalmol Vis Sci 55(11):7166-76. doi: 10.1167/iovs.14-15168. 2014
Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions.
Bays JL, Peng X, Tolbert CE, Guilluy C, Angell AE, Pan Y, Superfine R, Burridge K, DeMali KA.
J Cell Biol 205(2):251-63. doi: 10.1083/jcb.201309092. Epub 2014 Apr 21. 2014
Identification of an actin binding surface on vinculin that mediates mechanical cell and focal adhesion properties.
Thompson PM, Tolbert CE, Shen K, Kota P, Palmer SM, Plevock KM, Orlova A, Galkin VE, Burridge K, Egelman EH, Dokholyan NV, Superfine R, Campbell SL.
Structure 22(5):697-706. doi: 10.1016/j.str.2014.03.002. Epub 2014 Mar 27. 2014
Vinculin regulates osteoclast function.
Fukunaga T, Zou W, Warren JT, Teitelbaum SL.
J Biol Chem 289(19):13554-64. doi: 10.1074/jbc.M114.550731. Epub 2014 Mar 27. 2014
Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes.
Zemljic-Harpf AE, Godoy JC, Platoshyn O, Asfaw EK, Busija AR, Domenighetti AA, Ross RS.
J Cell Sci 127(Pt 5):1104-16. doi: 10.1242/jcs.143743. Epub 2014 Jan 10. 2014
Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes.
Zemljic-Harpf AE, Godoy JC, Platoshyn O, Asfaw EK, Busija AR, Domenighetti AA, Ross RS.
J Cell Sci 127(Pt 5):1104-16. doi: 10.1242/jcs.143743. Epub 2014 Jan 10. 2014
Vinculin arrests motile B cells by stabilizing integrin clustering at the immune synapse.
Saez de Guinoa J, Barrio L, Carrasco YR.
J Immunol 191(5):2742-51. doi: 10.4049/jimmunol.1300684. Epub 2013 Jul 19. 2013
Deletion of the cell adhesion adaptor protein vinculin disturbs the localization of GFAP in Bergmann glial cells.
Winkler U, Hirrlinger PG, Sestu M, Wilhelm F, Besser S, Zemljic-Harpf AE, Ross RS, Bornschein G, Krügel U, Ziegler WH, Hirrlinger J.
Glia 61(7):1067-83. doi: 10.1002/glia.22495. Epub 2013 Apr 17. 2013
Novel role for vinculin in ventricular myocyte mechanics and dysfunction.
Tangney JR, Chuang JS, Janssen MS, Krishnamurthy A, Liao P, Hoshijima M, Wu X, Meininger GA, Muthuchamy M, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens JH.
Biophys J 104(7):1623-33. doi: 10.1016/j.bpj.2013.02.021. 2013
RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover.
Goult BT, Zacharchenko T, Bate N, Tsang R, Hey F, Gingras AR, Elliott PR, Roberts GC, Ballestrem C, Critchley DR, Barsukov IL.
J Biol Chem 288(12):8238-49. doi: 10.1074/jbc.M112.438119. Epub 2013 Feb 6. 2013
Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner.
Carisey A, Tsang R, Greiner AM, Nijenhuis N, Heath N, Nazgiewicz A, Kemkemer R, Derby B, Spatz J, Ballestrem C.
Curr Biol 23(4):271-81. doi: 10.1016/j.cub.2013.01.009. Epub 2013 Jan 31. 2013
Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling.
Huveneers S, Oldenburg J, Spanjaard E, van der Krogt G, Grigoriev I, Akhmanova A, Rehmann H, de Rooij J.
J Cell Biol. 196(5):641-52. 2012
The metavinculin tail domain directs constitutive interactions with raver1 and vinculin RNA.
Lee JH, Rangarajan ES, Vonrhein C, Bricogne G, Izard T.
J Mol Biol 422(5):697-704. doi: 10.1016/j.jmb.2012.06.015. Epub 2012 Jun 15. 2012
Vinculin functions as regulator of chondrogenesis.
Koshimizu T, Kawai M, Kondou H, Tachikawa K, Sakai N, Ozono K, Michigami T.
J Biol Chem 287(19):15760-75. doi: 10.1074/jbc.M111.308072. Epub 2012 Mar 13. 2012
The C-terminal tail domain of metavinculin, vinculin's splice variant, severs actin filaments.
Janssen ME, Liu H, Volkmann N, Hanein D.
J Cell Biol 197(5):585-93. doi: 10.1083/jcb.201111046. Epub 2012 May 21. 2012
Vinculin's C-terminal region facilitates phospholipid membrane insertion.
Wirth VF, List F, Diez G, Goldmann WH.
Biochem Biophys Res Commun. 398(3):433-7. 2010
Lipid binding to the tail domain of vinculin: specificity and the role of the N and C termini.
Palmer SM, Playford MP, Craig SW, Schaller MD, Campbell SL.
J Biol Chem 284(11):7223-31. Epub 2008 Dec 24. 2009
Dystrophin-glycoprotein complex and vinculin-talin-integrin system in human adult cardiac muscle.
Anastasi G, Cutroneo G, Gaeta R, Di Mauro D, Arco A, Consolo A, Santoro G, Trimarchi F, Favaloro A.
Int J Mol Med 23(2):149-59.PMID: 19148538 2009
Vinculin and cellular retinol-binding protein-1 are markers for quiescent and activated hepatic stellate cells in formalin-fixed paraffin embedded human liver.
Van Rossen E, Vander Borght S, van Grunsven LA, Reynaert H, Bruggeman V, Blomhoff R, Roskams T, Geerts A.
Histochem Cell Biol 131(3):313-25. Epub 2008 Dec 4.PMID: 19052772 2009
Direct evidence of vinculin tail-lipid membrane interaction in beta-sheet conformation.
Diez G, List F, Smith J, Ziegler WH, Goldmann WH.
Biochem Biophys Res Commun 373(1):69-73. Epub 2008 Jun 11. 2008
Vinculin controls focal adhesion formation by direct interactions with talin and actin.
Humphries JD, Wang P, Streuli C, Geiger B, Humphries MJ, Ballestrem C.
J Cell Biol 179(5):1043-57. 2007
Myosin VI and vinculin cooperate during the morphogenesis of cadherin cell cell contacts in mammalian epithelial cells.
Maddugoda MP, Crampton MS, Shewan AM, Yap AS.
J Cell Biol. 178(3):529-40 2007
Identification of a metavinculin missense mutation, R975W, associated with both hypertrophic and dilated cardiomyopathy.
Vasile VC, Will ML, Ommen SR, Edwards WD, Olson TM, Ackerman MJ.
Mol Genet Metab 87(2):169-74. Epub 2005 Oct 19. 2006
Structural dynamics of alpha-actinin-vinculin interactions.
Bois PR, Borgon RA, Vonrhein C, Izard T.
Mol Cell Biol. 25(14):6112-22. 2005
Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.
Critchley DR.
Biochem Soc Trans 32(Pt 5):831-6. Review. 2004
The phosphorylation of vinculin on tyrosine residues 100 and 1065, mediated by SRC kinases, affects cell spreading.
Zhang Z, Izaguirre G, Lin SY, Lee HY, Schaefer E, Haimovich B.
Mol Biol Cell. 15(9):4234-47. 2004
Vinculin activation by talin through helical bundle conversion.
Izard T, Evans G, Borgon RA, Rush CL, Bricogne G, Bois PR.
Nature. 427(6970):171-5. 2004
Dilated cardiomyopathy: a genetically heterogeneous disease.
Shaw T,Elliott P,McKenna WJ.
Lancet 360(31):654-655. 2002
A lipid-regulated docking site on vinculin for protein kinase C.
Ziegler WH, Tigges U, Zieseniss A, Jockusch BM.
J Biol Chem. 277(9):7396-404. 2002
Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins.
Huttelmaier S, Illenberger S, Grosheva I, Rudiger M, Singer RH, Jockusch BM.
J Cell Biol 155(5):775-86. Epub 2001 Nov 26. 2001
Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation.
Geng L, Burrow CR, Li HP, Wilson PD.
Biochim Biophys Acta. 1535(1):21-35. 2000
Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin.
Harbeck B, Hüttelmaier S, Schluter K, Jockusch BM, Illenberger S.
J Biol Chem. 275(40):30817-25. 2000
A neurally enriched coronin-like protein, ClipinC, is a novel candidate for an actin cytoskeleton-cortical membrane-linking protein.
Nakamura T, et al.
J Biol Chem 274(19):13322-7 1999
alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells.
Watabe-Uchida M, Uchida N, Imamura Y, Nagafuchi A, Fujimoto K, Uemura T, Vermeulen S, van Roy F, Adamson ED, Takeichi M.
J Cell Biol. 142(3):847-57. 1998
Vinculin knockout results in heart and brain defects during embryonic development.
Xu W, Baribault H, Adamson ED.
Development. 125(2):327-37. 1998
Vinculin is associated with the E-cadherin adhesion complex.
Hazan RB, Kang L, Roe S, Borgen PI, Rimm DL.
J Biol Chem. 272(51):32448-53. 1997
Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding.
Brown MC, Perrotta JA, Turner CE.
J Cell Biol. 135(4):1109-23. 1996
F-actin binding site masked by the intramolecular association of vinculin head and tail domains.
Johnson RP, Craig SW.
Nature. 373(6511):261-4. 1995
Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region.
Turner CE, Miller JT.
J Cell Sci. 107 ( Pt 6):1583-91. 1994
Interaction of vinculin with the clathrin heavy chain.
Fausser JL, Ungewickell E, Ruch JV, Lesot H.
J Biochem. 114(4):498-503. 1993
Complementary physical and genetic techniques map the vinculin (VCL) gene on chromosome 10q.
Mulligan LM, et al.
Genomics 13 : 1347-1349. 1992
An SphI polymorphism at the vinculin locus (VCL).
Mulligan LM, et al.
Hum Mol Genet 1 : 550. 1992
Complete sequence of human vinculin and assignment of the gene to chromosome 10.
Weller PA, et al.
Proc Natl Acad Sci U S A 87 : 5667-5671. 1990