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FLASH GENE
Symbol SULT2A1 contributors: mct - updated : 12-03-2008
HGNC name sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1
HGNC id 11458
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
the FSSKA sequence motif common to hydroxysteroid SULT family
HOMOLOGY
interspecies homolog to murine Sult2a1
Homologene
FAMILY sulfotransferase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • sulfotransferase, a major adrenal steroid, precursor for androgen and estrogen biosynthesis in peripheral tissues
  • catalyzing the formation of DHEA-S
  • involved in the fine control of target cell sensitivity to hormone action
  • playing a potential role in the inherited adrenal androgen excess of polycystic ovary syndrome
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS