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FLASH GENE
Symbol SULT2A1 contributors: mct - updated : 12-03-2008
HGNC name sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1
HGNC id 11458
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1779 - 285 - Goodarzi (2007)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestinejejunum  
 liver   highly
Endocrineadrenal glandcortex   
 parathyroid    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver, adrenal, kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
the FSSKA sequence motif common to hydroxysteroid SULT family
HOMOLOGY
interspecies homolog to murine Sult2a1
Homologene
FAMILY sulfotransferase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • sulfotransferase, a major adrenal steroid, precursor for androgen and estrogen biosynthesis in peripheral tissues
  • catalyzing the formation of DHEA-S
  • involved in the fine control of target cell sensitivity to hormone action
  • playing a potential role in the inherited adrenal androgen excess of polycystic ovary syndrome
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS