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FLASH GENE

Symbol

SULT2A1

contributors: mct - updated : 12-03-2008

HGNC name	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1
HGNC id	11458

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.3      Physical location : 48.373.722 - 48.389.654
Synonym name	dehydroepiandrosterone sulfotransferase
	hydroxysteroid sulfotransferase
	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
Synonym symbol(s)	STD, DHEA-ST, ST2, ST2A3, STD, hSTa
EC.number	2.8.2.2

DNA

TYPE	functioning gene
STRUCTURE	15.00 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	cen - D19S224 - D19S420 - D19S217 - APOC2 APOC2 ,D19S412 - SULT2A1 - HRC - KLK1 /KLK2 - D19S22 - D19S180 - PRKCG - D19S418 - qter
Authors	Durocher (95)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 6 - 1779 - 285 - Goodarzi (2007)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine jejunum       liver       highly Endocrine adrenal gland cortex         parathyroid

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	liver, adrenal, kidney

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

the FSSKA sequence motif common to hydroxysteroid SULT family

HOMOLOGY

interspecies

homolog to murine Sult2a1

Homologene

FAMILY

sulfotransferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	sulfotransferase, a major adrenal steroid, precursor for androgen and estrogen biosynthesis in peripheral tissues
	catalyzing the formation of DHEA-S
	involved in the fine control of target cell sensitivity to hormone action
	playing a potential role in the inherited adrenal androgen excess of polycystic ovary syndrome

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS