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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

CDH3

contributors: mct/pgu - updated : 25-03-2011

HGNC name	cadherin 3, type 1, P-cadherin (placental)
HGNC id	1762

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HJMD , EEM

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     loss of a complex formed with the beta-catenin in poorly differentiated esophageal squamous carcinoma tumoral     --over   malignant melanoma tumoral     --over   in breast cancer cells with wild-type CDH1, promotes cell invasion, motility and migration tumoral     --over   by demethylation in advanced colorectal carcinomas

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer endocrine pancreas novel tumor-associated antigen useful for immunotherapy against a broad spectrum of cancers, including pancreatic cancer

ANIMAL & CELL MODELS