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FLASH GENE

Symbol

PRDX2

contributors: np/shn - updated : 03-09-2014

HGNC name	peroxiredoxin 2
HGNC id	9353

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   induces neurodegeneration through oxidative damage, and enhancing Parkinson disease constitutional     --over   in end-stage dilated cardiomyopathy

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	may be potential targets for neuroprotective intervention in Parkinson's disease (
	System Type Disorder Pubmed cardiovascular atheroma   specific activation of PRDX2 may be an effective means of antiatherogenic therapy

ANIMAL & CELL MODELS

	down-regulated PRDX2 through stable transfections of SH-SY5Y neuroblastoma cells with antisense contructs of the complete PRDX2 coding sequence display sensitivity to oxidative stress in addition to increased apoptosis under basal conditions and after treatment with oxidative cytotoxic agents (
	PRX2 overexpression conferred marked in vitro and in vivo neuroprotection against 6-OHDA toxicity and anti-apoptotic effects in dopaminergic neurons, and preserved motor functions involving the dopamine system in mouse (
	deficiency of Prdx2 in apolipoprotein E-deficient (ApoE(-/-) mice accelerated plaque formation with enhanced activation of RELA, JUN, JNKs, and MAPK14
	loss of Prx II accelerates Heinz body formation by oxidative stress in mice, and increased Heinz body formation in Prx II-/- was mainly caused by denatured Hb aggregation