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Symbol PRDX2 contributors: np/shn - updated : 03-09-2014
HGNC name peroxiredoxin 2
HGNC id 9353
  • down-regulated PRDX2 through stable transfections of SH-SY5Y neuroblastoma cells with antisense contructs of the complete PRDX2 coding sequence display sensitivity to oxidative stress in addition to increased apoptosis under basal conditions and after treatment with oxidative cytotoxic agents (
  • PRX2 overexpression conferred marked in vitro and in vivo neuroprotection against 6-OHDA toxicity and anti-apoptotic effects in dopaminergic neurons, and preserved motor functions involving the dopamine system in mouse (
  • deficiency of Prdx2 in apolipoprotein E-deficient (ApoE(-/-) mice accelerated plaque formation with enhanced activation of RELA, JUN, JNKs, and MAPK14
  • loss of Prx II accelerates Heinz body formation by oxidative stress in mice, and increased Heinz body formation in Prx II-/- was mainly caused by denatured Hb aggregation