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FLASH GENE
Symbol PRDX2 contributors: np/shn - updated : 03-09-2014
HGNC name peroxiredoxin 2
HGNC id 9353
DNA
TYPE functioning gene
STRUCTURE 5.06 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map pter - D19S906 - D19S221 - PRDX2 - D19S914 - D19S840 - cen
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 splicing 1039 21.8 198 - 1995 7607688
3 splicing 710 15.8 142 - 1995 7607688
  • using an alternative splice site compared to variant 1, which results in a translational frameshift
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyeanterior segmentiris   Homo sapiens
     eyeretina    Homo sapiens
     eyesclera    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral    Homo sapiensFetal
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythrocyte Homo sapiens
    Nervousglia Homo sapiens
    Nervousneuron Homo sapiens
    Visualcone photoreceptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain of PRDX2 is necessary for its binding to Hb
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to yeast thioredoxin-dependent peroxide reductase (TPX)
    ortholog to Prdx2, Rattus norvegicus
    ortholog to Prdx2, Mus musculus
    homolog to drosophila Jafrac1
    ortholog to prdx2, Danio rerio
    ortholog to PRDX2, Pan troglodytes
    Homologene
    FAMILY
  • thioredoxin peroxidase family
  • peroxiredoxin protein family
  • ahpC/TSA family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • strong cytoplasmic labeling in the basal cells of the corneal epithelial layer and the corneoscleral limbus
  • localized mainly in the nucleus of neural cells
  • basic FUNCTION
  • may be playing an important role in eliminating peroxides generated during metabolism
  • involved in redox regulation of the cell
  • reducing peroxides with reducing equivalents provided through the thioredoxin system
  • might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)
  • enhancing natural killer (NK) cells activity
  • acting as a negative regulator of PDGF signaling
  • have a role in both the resistance of certain cancers to therapy and quite a different role in possibly slowing the progression of neurodegenerative diseases
  • functioning as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte and having nonredundant role in erythrocyte defense against oxidative stress
  • thiol-specific peroxidase, that regulate proinflammatory responses, vascular remodeling, and global oxidative stress
  • pecific peroxidase that inhibits atherogenic responses in vascular and inflammatory cells
  • has been shown to regulate diverse biological functions as cell proliferation and planar cell polarity, and also to affect wound healing
  • PRDX2 functions are modulated in response to oxidative stress in diseased Red blood cells
  • protects cells from deleterious oxidative damage
  • PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    antioxidant
    a component
  • disulfide-linked homodimer
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a novel interacting partner to Hb in Red blood cells, the interaction of these two proteins could be construed as a novel form of PRDX2 protection against Hb instability
  • hyperoxidized PRDX2 interacts with the protein disulfide- isomerase TXNDC5
  • cell & other
    REGULATION
    Other phosphorylated by CDK5
    oxidized by endogenously generated H(2)O(2), which was mainly derived from hemoglobin autoxidation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    induces neurodegeneration through oxidative damage, and enhancing Parkinson disease
    constitutional     --over  
    in end-stage dilated cardiomyopathy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • may be potential targets for neuroprotective intervention in Parkinson's disease (
  • SystemTypeDisorderPubmed
    cardiovascularatheroma 
    specific activation of PRDX2 may be an effective means of antiatherogenic therapy
    ANIMAL & CELL MODELS
  • down-regulated PRDX2 through stable transfections of SH-SY5Y neuroblastoma cells with antisense contructs of the complete PRDX2 coding sequence display sensitivity to oxidative stress in addition to increased apoptosis under basal conditions and after treatment with oxidative cytotoxic agents (
  • PRX2 overexpression conferred marked in vitro and in vivo neuroprotection against 6-OHDA toxicity and anti-apoptotic effects in dopaminergic neurons, and preserved motor functions involving the dopamine system in mouse (
  • deficiency of Prdx2 in apolipoprotein E-deficient (ApoE(-/-) mice accelerated plaque formation with enhanced activation of RELA, JUN, JNKs, and MAPK14
  • loss of Prx II accelerates Heinz body formation by oxidative stress in mice, and increased Heinz body formation in Prx II-/- was mainly caused by denatured Hb aggregation