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FLASH GENE

Symbol

KRT17

contributors: mct/npt/pgu - updated : 08-06-2018

HGNC name	keratin 17
HGNC id	6427

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	conserved central rod domain
	four helical domains (1A, 1B, 2A, 2B) interrupted by non alpha helical linkers (L1, 2, 3) and flanked by the homology domain H1
	variable region (V1, V2) and end sequences (E1, E2)

mono polymer

heteromer , tetramer

HOMOLOGY

Homologene

FAMILY	intermediate filaments family
	type I keratin family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,intermed filament

basic FUNCTION	may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells"
	regulating cell growth through binding to the adaptor protein 14-3-3sigma
	immunomodulatory role in Hedgehog driven basaloid skin tumors that could impact additional tumor settings, psoriasis and wound repair

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with TNF (acting as two novel and interdependent regulators of hair cycling)
	IPO13 may contribute to the pathogenesis of pterygium via modulation of KRT17 and JUN

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PC217 , STM

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed dermatology skin   potentially attractive target for new therapies aimed at curtailing conditions driven by or linked to chronic cutaneous inflammation

ANIMAL & CELL MODELS