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FLASH GENE
Symbol KRT17 contributors: mct/npt/pgu - updated : 08-06-2018
HGNC name keratin 17
HGNC id 6427
DNA
TYPE functioning gene
STRUCTURE 5.12 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1574 48.1 432 - 2007 17719747
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratoryrespiratory tractlarynx  highly
Skin/Tegumentskin appendagesnails   
 skin appendageshairfollicle  
 skin appendagesskin glandsebaceous gland  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved central rod domain
  • four helical domains (1A, 1B, 2A, 2B) interrupted by non alpha helical linkers (L1, 2, 3) and flanked by the homology domain H1
  • variable region (V1, V2) and end sequences (E1, E2)
  • mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • intermediate filaments family
  • type I keratin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • may be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells"
  • regulating cell growth through binding to the adaptor protein 14-3-3sigma
  • immunomodulatory role in Hedgehog driven basaloid skin tumors that could impact additional tumor settings, psoriasis and wound repair
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TNF (acting as two novel and interdependent regulators of hair cycling)
  • IPO13 may contribute to the pathogenesis of pterygium via modulation of KRT17 and JUN
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PC217 , STM
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    dermatologyskin 
    potentially attractive target for new therapies aimed at curtailing conditions driven by or linked to chronic cutaneous inflammation
    ANIMAL & CELL MODELS