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FLASH GENE

Symbol

NPPB

contributors: mct - updated : 06-05-2015

HGNC name	natriuretic peptide precursor B
HGNC id	7940

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   increasing progressively with worsening symptoms in severe mitral regurgitation constitutional     --over   transiently increased in patients with intracerebal large-artery atherosclerosis independently of heart disease, and reflected infarct volume and the severity of acute ischemic stroke constitutional     --over   plasma concentrations correlate with the extent of atrial fibrillation-associated silent brain lesions constitutional     --over   significant predictors of death and/or complicated clinical course in acute pulmonary embolism constitutional     --over   significantly with severity of mitral regurgitation secondary to ischemic and nonischemic dilated cardiomyopathy constitutional     --over   of TNNT2 and NPPB are associated with increased risk of cardioembolic and other nonlacunar ischemic strokes

Susceptibility

to postmenopausal osteoporosis type 2 diabetes to blood pressure variation

Variant & Polymorphism other	variant increasing the risk of postmenopausal osteoporosis
	T-381C polymorphism was associated with lower plasma glucose levels and lower type 2 diabetes risk, and with higher bone-mineral density in Japanese postmenopausal women
	Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension

Candidate gene
Marker	marker of preeclampsia (concentration of NPPB was higher in pre-eclamptic women, and is associated with the (TTTC) genotypes)
	NPPB and TNNI3 are useful markers for identifying patients at risk for clinical deteriorations, and combined measurements of these biomarkers further improves the prognostic value of increased cardiovascular events in hypertrophic cardiomyopathy (HCM)
	plasma NPPB was found to be an independent predictor of endothelial function
	vis a useful diagnostic marker of acute Kawasaki disease in children
	used as a therapeutic and a biomarker for heart failure (HF)
	predictive of all-cause mortality, suggesting that this biomarker may potentially be used to refine clinical risk stratification in anticoagulated patients with atrial fibrillation
Therapy target	BNP level is significant and equivalent indicator of coronary artery disease and left ventricular hypertrophy in asymptomatic patients with chronic kidney disease
	induction of NPPB may contribute to the potential benefits of pharmacological HIF inducers in the treatment of ischaemic heart disease and heart failure

ANIMAL & CELL MODELS