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FLASH GENE

Symbol

FEN1

contributors: shn/pgu - updated : 09-09-2015

HGNC name	flap structure-specific endonuclease 1
HGNC id	3650

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       mutated in Cockayne syndrome, severe form tumoral     --over   in lung cancer tumoral somatic mutation       abrogated two of three nuclease activities of flap endonuclease 1 in several cancer

Susceptibility

to developing breast cancer to glioma

Variant & Polymorphism SNP	FEN1-69GG genotypes were significantly correlated to increased risk for developing breast cancer compared with the -69AA genotype
	FEN1-69GG or 4150GG genotype were significantly associated to increased glioma risk

Candidate gene
Marker	is a promising biomarker in breast and ovarian epithelial cancer
Therapy target

ANIMAL & CELL MODELS

Fen1 depleted null mice showed embryonic lethality and the blastocysts displayed proliferation failure and increased sensitivity to gamma radiation