Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol FEN1 contributors: shn/pgu - updated : 09-09-2015
HGNC name flap structure-specific endonuclease 1
HGNC id 3650
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional germinal mutation      
mutated in Cockayne syndrome, severe form
tumoral     --over  
in lung cancer
tumoral somatic mutation      
abrogated two of three nuclease activities of flap endonuclease 1 in several cancer
Susceptibility
  • to developing breast cancer
  • to glioma
  • Variant & Polymorphism SNP
  • FEN1-69GG genotypes were significantly correlated to increased risk for developing breast cancer compared with the -69AA genotype
  • FEN1-69GG or 4150GG genotype were significantly associated to increased glioma risk
  • Candidate gene
    Marker
  • is a promising biomarker in breast and ovarian epithelial cancer
  • Therapy target
    ANIMAL & CELL MODELS
  • Fen1 depleted null mice showed embryonic lethality and the blastocysts displayed proliferation failure and increased sensitivity to gamma radiation