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FLASH GENE

Symbol

NOTCH3

contributors: mct - updated : 28-05-2016

HGNC name	Notch homolog 3 (Drosophila)
HGNC id	7883

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CADASIL , HMID , IMF2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     in acute lymphoblastic/myeloblastic leukemia tumoral     --over   in lung cancer constitutional     --over   in small pulmonary artery smooth muscle cells associated with pulmonary hypertension constitutional     --over   in immune thrombocytopenic purpura constitutional     --over   in fibrotic liver tissues of patients with chronic active hepatitis, but not detected in normal liver tissues

Susceptibility

Variant & Polymorphism

Candidate gene	NOTCH3-HES5 signaling pathway is crucial for the development of pulmonary arterial hypertension
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous hypertension   inhibition of the expression or effect of NOTCH3 signaling in the adult pulmonary vasculature may be a useful strategy to prevent and treat pulmonary arterial hypertension cancer reproductive ovary expression may be related to chemoresistance and that the Notch3 pathway may represent a novel therapeutic target for advanced stage chemoresistant ovarian cancer digestive liver   selective interruption of NOTCH3 may provide an anti-fibrotic strategy in hepatic fibrosis cancer angiogenesis   JAG1/NOTCH3 is expected to be a potential target for TNBC neovascularization therapy

ANIMAL & CELL MODELS

when Notch2 and Notch3 genes are simultaneously disrupted, mice die in utero at mid-gestation due to severe vascular abnormalities