| 1 | NOTCH1, NOTCH2, NOTCH3, NOTCH4
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| Notch and the regulation of osteoclast differentiation and function.
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| Yu J, Canalis E.
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| Bone Jun 8:115474. doi: 10.1016/j.bone.2020.115474. Online ahead of print 2020
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| 2 | JAG1, NOTCH3
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| Expression of Jagged1/Notch3 Signaling Pathway and their Relationship with the Tumor Angiogenesis in TNBC.
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| Xue S, He L, Zhang X, Zhou J, Li F, Wang X.
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| Arch Med Res 48(2):169-179. doi: 10.1016/j.arcmed.2017.03.014.
2017
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| 3 | NOTCH2, NOTCH3
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| Effects of Notch2 and Notch3 on Cell Proliferation and Apoptosis of Trophoblast Cell Lines.
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| Zhao WX, Zhuang X, Huang TT, Feng R, Lin JH.
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| Int J Med Sci 12(11):867-74. doi: 10.7150/ijms.12935. eCollection 2015.
2015
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| 4 | NOTCH2, NOTCH3
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| Loss of Notch2 and Notch3 in vascular smooth muscle causes patent ductus arteriosus.
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| Baeten JT, Jackson AR, McHugh KM, Lilly B.
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| Genesis 53(12):738-48. doi: 10.1002/dvg.22904. Epub 2015 Oct 30.
2015
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| 5 | NOTCH2, NOTCH3, PDGFB
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| Differential Regulation of NOTCH2 and NOTCH3 Contribute to Their Unique Functions in Vascular Smooth Muscle Cells.
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| Baeten JT, Lilly B.
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| J Biol Chem 290(26):16226-37. doi: 10.1074/jbc.M115.655548. Epub 2015 May 8.
2015
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| 6 | CCNG1, MDM2, NOTCH3, TP53
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| Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinoma.
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| Giovannini C, Minguzzi M, Baglioni M, Fornari F, Giannone F, Ravaioli M, Cescon M, Chieco P, Bolondi L, Gramantieri L.
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| Oncotarget 5(21):10607-20.
2014
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| 7 | CTCFL, NOTCH3
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| The epigenetic factor BORIS/CTCFL regulates the NOTCH3 gene expression in cancer cells.
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| Zampieri M, Ciccarone F, Palermo R, Cialfi S, Passananti C, Chiaretti S, Nocchia D, Talora C, Screpanti I, Caiafa P.
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| Biochim Biophys Acta 1839(9):813-25. doi: 10.1016/j.bbagrm.2014.06.017. Epub 2014 Jun 28.
2014
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| 8 | JAG1, NOTCH3
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| Overexpression of the Notch3 receptor and its ligand Jagged1 in human clinically non-functioning pituitary adenomas.
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| Lu R, Gao H, Wang H, Cao L, Bai J, Zhang Y.
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| Oncol Lett 5(3):845-851. Epub 2013 Jan 7.
2013
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| 9 | NOTCH3
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| Analysis of the expression of the Notch3 receptor protein in adult lung cancer.
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| Zhou M, Jin WY, Fan ZW, Han RC.
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| Oncol Lett 5(2):499-504. Epub 2012 Nov 19.
2013
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| 10 | IMF1, IMF2, NOTCH3, PDGFRB
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| Mutations in PDGFRB Cause Autosomal-Dominant Infantile Myofibromatosis.
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| Martignetti JA, Tian L, Li D, Ramirez MC, Camacho-Vanegas O, Camacho SC, Guo Y, Zand DJ, Bernstein AM, Masur SK, Kim CE, Otieno FG, Hou C, Abdel-Magid N, Tweddale B, Metry D, Fournet JC, Papp E, McPherson EW, Zabel C, Vaksmann G, Morisot C, Keating B, Sleiman PM, Cleveland JA, Everman DB, Zackai E, Hakonarson H.
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| Am J Hum Genet m J Hum Genet. 2013 May 22. doi:pii: S0002-9297(13)00211-5. 10.1016/j.ajhg.2013.04.024. [Epub ahead of print] 2013
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| 11 | IMF1, IMF2, NOTCH3, PDGFRB
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| Mutations in PDGFRB and NOTCH3 are the first genetic causes identified for autosomal dominant infantile myofibromatosis.
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| Lee JW.
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| Clin Genet 84(4):340-1. doi: 10.1111/cge.12238. Epub 2013 Jul 31. No abstract available.
2013
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| 12 | NOTCH3
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| Notch3 signaling gates cell cycle entry and limits neural stem cell amplification in the adult pallium
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| Alunni A, Krecsmarik M, Bosco A, Galant S, Pan L, Moens CB, Bally-Cuif L.
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| Development. Aug;140(16):3335-47. doi: 10.1242/dev.095018. Epub 2013 Jul 17. 2013
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| 13 | NOTCH3
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| Notch3 overexpression as potential therapeutic target in advanced stage chemoresistant ovarian cancer.
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| Rahman MT, Nakayama K, Rahman M, Katagiri H, Katagiri A, Ishibashi T, Ishikawa M, Iida K, Nakayama S, Otsuki Y, Miyazaki K.
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| Am J Clin Pathol 138(4):535-44.
2012
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| 14 | CADASIL, NOTCH3
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| CADASIL mutations and shRNA silencing of NOTCH3 affect actin organization in cultured vascular smooth muscle cells.
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| Tikka S, Ng YP, Di Maio G, Mykkänen K, Siitonen M, Lepikhova T, Pöyhönen M, Viitanen M, Virtanen I, Kalimo H, Baumann M.
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| J Cereb Blood Flow Metab 32(12):2171-80. doi: 10.1038/jcbfm.2012.123. Epub 2012 Sep 5.
2012
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| 15 | NOTCH2, NOTCH3
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| Notch2 and Notch3 function together to regulate vascular smooth muscle development.
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| Wang Q, Zhao N, Kennard S, Lilly B.
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| PLoS One 7(5):e37365. doi: 10.1371/journal.pone.0037365. Epub 2012 May 17.
2012
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| 16 | NOTCH3
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| Notch3 regulates the activation of hepatic stellate cells.
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| Chen YX, Weng ZH, Zhang SL.
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| World J Gastroenterol 18(12):1397-403. doi: 10.3748/wjg.v18.i12.1397.
2012
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| 17 | NOTCH3
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| Ultrastructural changes in cerebral capillary pericytes in aged Notch3 mutant transgenic mice.
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| Gu X, Liu XY, Fagan A, Gonzalez-Toledo ME, Zhao LR.
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| Ultrastruct Pathol 36(1):48-55. doi: 10.3109/01913123.2011.620220.
2012
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| 18 | NOTCH2, NOTCH3, SDC2
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| Reciprocal regulation of syndecan-2 and Notch signaling in vascular smooth muscle cells.
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| Zhao N, Liu H, Lilly B.
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| J Biol Chem 287(20):16111-20. doi: 10.1074/jbc.M111.322107. Epub 2012 Mar 21.
2012
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| 19 | APOD, NOTCH3
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| Endothelial cells downregulate apolipoprotein D expression in mural cells through paracrine secretion and Notch signaling.
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| Pajaniappan M, Glober NK, Kennard S, Liu H, Zhao N, Lilly B.
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| Am J Physiol Heart Circ Physiol 301(3):H784-93. Epub 2011 Jun 24.
2011
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| 20 | CADASIL, NOTCH3
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| Co-aggregate formation of CADASIL-mutant NOTCH3: a single-particle analysis.
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| Duering M, Karpinska A, Rosner S, Hopfner F, Zechmeister M, Peters N, Kremmer E, Haffner C, Giese A, Dichgans M, Opherk C.
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| Hum Mol Genet 20(16):3256-65. Epub 2011 May 30.
2011
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| 21 | CADASIL, NOTCH3
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| Shorter telomeres in patients with cerebral autosomal dominant arteriopathy and leukoencephalopathy (CADASIL).
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| Ragno M, Pianese L, Pinelli M, Silvestri S, Cacchiò G, Di Marzio F, Scarcella M, Coretti F, Altamura F, Monticelli A, Castaldo I.
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| Neurogenetics 12(4):337-43. doi: 10.1007/s10048-011-0298-1. Epub 2011 Sep 1.
2011
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| 22 | BCL2L11, EGFR, NOTCH3
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| Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim.
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| Konishi J, Yi F, Chen X, Vo H, Carbone DP, Dang TP.
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| Oncogene 29(4):589-96. Epub 2009 Nov 2.
2010
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| 23 | CADASIL, NOTCH3
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| Mutations in NOTCH3 cause the formation and retention of aggregates in the endoplasmic reticulum, leading to impaired cell proliferation.
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| Takahashi K, Adachi K, Yoshizaki K, Kunimoto S, Kalaria RN, Watanabe A.
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| Hum Mol Genet 19(1):79-89. Epub .PMID: 19825845 2010
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| 24 | NOTCH1, NOTCH2, NOTCH3
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| Aberrant expression of Notch signaling molecules in patients with immune thrombocytopenic purpura.
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| Ma D, Dai J, Zhu X, Yan S, Zhao P, Zhang J, Zhu Y, Sun J, Peng J, Ji C, Hou M.
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| Ann Hematol 89(2):155-61. Epub 2009 Jul 15.PMID: 19603167 2010
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| 25 | CADASIL, NOTCH3
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| CADASIL mutations enhance spontaneous multimerization of NOTCH3.
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| Opherk C, Duering M, Peters N, Karpinska A, Rosner S, Schneider E, Bader B, Giese A, Dichgans M.
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| Hum Mol Genet 18(15):2761-7. Epub 2009 May 5.
2009
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| 26 | HES5, NOTCH3
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| Notch3 signaling promotes the development of pulmonary arterial hypertension.
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| Li X, Zhang X, Leathers R, Makino A, Huang C, Parsa P, Macias J, Yuan JX, Jamieson SW, Thistlethwaite PA.
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| Nat Med 15(11):1289-97. Epub 2009 Oct 25. 2009
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| 27 | NOTCH1, NOTCH2, NOTCH3, JAG1, ICHD, PSEN1, PSEN2
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| The multifaceted role of Notch in cardiac development and disease.
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| High FA, Epstein JA.
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| Nat Rev Genet 9(1):49-61. Review. 2008
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| 28 | CADASIL, NOTCH3
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| Autosomal dominant leukoencephalopathy with mild clinical symptoms due to cerebrovascular dysfunctions: a new disease entity?
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| Hirabayashi S, Wada T, Kondo Y, Arima K.
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| Brain Dev 30(2):146-50. Epub 2007 Jul 25.PMID: 17656057 2008
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| 29 | HEY1, MSX1, NOTCH3, PHOX2B
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| The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta-Notch pathway in neuroblastoma.
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| Revet I, Huizenga G, Chan A, Koster J, Volckmann R, van Sluis P, Øra I, Versteeg R, Geerts D.
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| Exp Cell Res 314(4):707-19. Epub 2008 Jan 16.PMID: 18201699 2008
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| 30 | CADASIL, NOTCH3
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| A pathogenic mutation on exon 21 of the NOTCH3 gene causing CADASIL in an octogenarian paucisymptomatic patient.
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| Pescini F, Bianchi S, Salvadori E, Poggesi A, Dotti MT, Federico A, Inzitari D, Pantoni L.
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| J Neurol Sci 267(1-2):170-3. Epub 2007 Nov 19.PMID: 18022198 2008
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| 31 | CADASIL, NOTCH3
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| Sporadic vascular dementia as clinical presentation of a new missense mutation within exon 7 of NOTCH3 gene.
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| Pradotto L, Azan G, Doriguzzi C, Valentini C, Mauro A.
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| J Neurol Sci 271(1-2):207-10. Epub 2008 May 21.
2008
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| 32 | NOTCH3
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| Conserved signal peptide of Notch3 inhibits interaction with proteasome.
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| Zhang Y, Jia L, Lee SJ, Wang MM.
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| Biochem Biophys Res Commun 355(1):245-51. Epub 2007 Feb 5. Erratum in: Biochem Biophys Res Commun. 2007 Aug 3;359(3):840. 2007
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| 33 | NOTCH3
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| Renal involvement in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
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| Kusaba T, Hatta T, Kimura T, Sonomura K, Tanda S, Kishimoto N, Kameyama H, Okigaki M, Mori Y, Ishigami N, Mizuno T, Nakagawa M, Matsubara H.
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| Clin Nephrol 67(3):182-7. 2007
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| 34 | CADASIL, HMID, NOTCH3
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| Hereditary multi-infarct dementia of the Swedish type is a novel disorder different from NOTCH3 causing CADASIL.
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| Low WC, Junna M, Börjesson-Hanson A, Morris CM, Moss TH, Stevens DL, St Clair D, Mizuno T, Zhang WW, Mykkänen K, Wahlstrom J, Andersen O, Kalimo H, Viitanen M, Kalaria RN.
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| Brain 130(Pt 2):357-67. 2007
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| 35 | CADASIL, NOTCH3
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| Lacunar lesions are independently associated with disability and cognitive impairment in CADASIL.
|
| Viswanathan A, Gschwendtner A, Guichard JP, Buffon F, Cumurciuc R, O'Sullivan M, Holtmannspötter M, Pachai C, Bousser MG, Dichgans M, Chabriat H.
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| Neurology 69(2):172-9.
2007
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| 36 | NOTCH1, NOTCH2, NOTCH3, NOTCH4
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| A role for notch signaling in human corneal epithelial cell differentiation and proliferation.
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| Ma A, Boulton M, Zhao B, Connon C, Cai J, Albon J.
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| Invest Ophthalmol Vis Sci 48(8):3576-85.PMID: 17652726 2007
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| 37 | NOTCH1,NOTCH2,NOTCH3,NOTCH4
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| Multiple functions of Notch signaling in self-renewing organs and cancer.
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| Wilson A, Radtke F.
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| FEBS Lett 580(12):2860-8. Epub 2006 Mar 20. 2006
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| 38 | NOTCH3
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| Notch3 signaling initiates choroid plexus tumor formation.
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| Dang L, Fan X, Chaudhry A, Wang M, Gaiano N, Eberhart CG.
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| Oncogene 25(3):487-91. 2006
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| 39 | NOTCH3, CADASIL
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| CADASIL mutations impair Notch3 glycosylation by Fringe.
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| Arboleda-Velasquez JF, Rampal R, Fung E, Darland DC, Liu M, Martinez MC, Donahue CP, Navarro-Gonzalez MF, Libby P, D'Amore PA, Aikawa M, Haltiwanger RS, Kosik KS.
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| Hum Mol Genet 14(12):1631-9. Epub 2005 Apr 27. 2005
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| 40 | NOTCH3, CADASIL
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| Arg332Cys mutation of NOTCH3 gene in the first known Taiwanese family with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
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| Tang SC, Lee MJ, Jeng JS, Yip PK.
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| J Neurol Sci 228(2):125-8. Epub 2004 Dec 24. 2005
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| 41 | CADASIL, NOTCH3, JAG1
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| Pathogenic Mutations Associated with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Differently Affect Jagged1 Binding and Notch3 Activity via the RBP/JK Signaling Pathway.
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| Joutel A, Monet M, Domenga V, Riant F, Tournier-Lasserve E.
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| Am J Hum Genet 74(2):338-47. Epub 2004 Jan 08. 2004
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| 42 | CADASIL, NOTCH3
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| Distribution pattern of Notch3 mutations suggests a gain-of-function mechanism for CADASIL.
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| Donahue CP, Kosik KS.
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| Genomics 83(1):59-65. 2004
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| 43 | NOTCH3, CADASIL
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| Detection of the founder effect in Finnish CADASIL families.
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| Mykkanen K, Savontaus ML, Juvonen V, Sistonen P, Tuisku S, Tuominen S, Penttinen M, Lundkvist J, Viitanen M, Kalimo H, Poyhonen M.
|
| Eur J Hum Genet 12(10):813-9. 2004
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| 44 | CADASIL, DLL1, Dll3, DLL4, JAG1, JAG2, NOTCH1, NOTCH2, NOTCH3, NOTCH4 , RBPJ, SCDO1
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| Notch signaling and inherited disease syndromes.
|
| Gridley T.
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| Hum Mol Genet 12 Spec No 1:R9-13. Review. 2003
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| 45 | ALPCA1,ALPCA2,NOTCH1,NOTCH2,NOTCH3,NOTCH4
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| Notch signaling in development and disease.
|
| Harper JA, Yuan JS, Tan JB, Visan I, Guidos CJ.
|
| Clin Genet 64(6):461-72. 2003
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| 46 | CADASIL, NOTCH3
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| Genetic, clinical and pathological studies of CADASIL in Japan: a partial contribution of Notch3 mutations and implications of smooth muscle cell degeneration for the pathogenesis.
|
| Santa Y, Uyama E, Chui de H, Arima M, Kotorii S, Takahashi K, Tabira T.
|
| J Neurol Sci 212(1-2):79-84. 2003
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| 47 | CADASIL, NOTCH3
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| A novel mitochondrial DNA mutation and a mutation in the Notch3 gene in a patient with myopathy and CADASIL.
|
| Finnila S, Tuisku S, Herva R, Majamaa K.
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| J Mol Med 79(11):641-7. 2001
|
| 48 | LFNG, MFNG, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NOTCH5, RFNG
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| Fringe is a glycosyltransferase that modifies Notch.
|
| Moloney DJ, Panin VM, Johnston SH, Chen J, Shao L, Wilson R, Wang Y, Stanley P, Irvine KD, Haltiwanger RS, Vogt TF.
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| Nature 406(6794):369-75. 2000
|
| 49 | LFNG, MFNG, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NOTCH5, RFNG
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| Glycosyltransferase activity of Fringe modulates Notch-Delta interactions.
|
| Bruckner K, Perez L, Clausen H, Cohen S.
|
| Nature 406(6794):411-5. 2000
|
| 50 | NOTCH1, NOTCH2, NOTCH3, NOTCH4, PSEN1
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| Presenilin is required for activity and nuclear access of Notch in Drosophila.
|
| Struhl G, et al.
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| Nature 398(6727):522-5. 1999
|
| 51 | NOTCH1, NOTCH2, NOTCH3, NOTCH4, PSEN1
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| A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
|
| De Strooper B, et al.
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| Nature 398(6727):518-22. 1999
|
| 52 | CADASIL, NOTCH3
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| Diagnostic Notch3 sequence analysis in CADASIL: three new mutations in Dutch patients. Dutch CADASIL Research Group.
|
| Oberstein SA, et al.
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| Neurology 52(9):1913-5. 1999
|
| 53 | NOTCH3
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| Notch signalling controls pancreatic cell differentiation.
|
| Apelqvist A, et al.
|
| Nature 400(6747):877-81. 1999
|
| 54 | CADASIL, NOTCH3
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| Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients.
|
| Joutel A, Vahedi K, Corpechot C, Troesch A, Chabriat H, Vayssiere C, Cruaud C, Maciazek J, Weissenbach J, Bousser MG, Bach JF, Tournier-Lasserve E.
|
| Lancet 350(9090):1511-5. 1997
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| 55 | CADASIL, NOTCH3
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| Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia.
|
| Joutel A, et al.
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| Nature 383 : 707-710. 1996
|
| 56 | NOTCH1, NOTCH2, NOTCH3
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| The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation.
|
| Larsson C, et al.
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| Genomics 24 : 253-258. 1994
|