motifs/domains
| a 19 aa signal peptide (2 kda) |
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an extracellular cysteine-rich ligand binding domain (heparin-binding site) |
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a single transmembrane (1TM) protein with extensive homology to the epidermal growth factor receptor, lacking the C terminal catalytic domain (kinase domain binds ATP, but is catalytically inactive and can serve as an activator of the EGFR kinase domain) |
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a furin-like cystein rich region |
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a tyrosine kinase catalytic domain |
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specific N-glycan in domain III playing an essential role in regulating receptor dimerization and transforming activity |
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a putative NLS with three clusters of basic amino acids (RRRHIVRKRTLRR (amino acids 645-657)) in the juxtamembrane region |
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a functional nuclear localization signal sequence ( |
| basic FUNCTION
| acting as a receptor tyrosine kinase |
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acting as a neuregulin beta 1 receptor low affinity |
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acting as an heregulin receptor |
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acting as an epidermal growth factor receptor |
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activator of the phosphatidylinositol-3-kinase/Akt pathway, regulating cell survival and vesicle trafficking, essential for the generation of precursors of Schwann cells that normally accompany peripheral axons of motor |
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neurons |
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regulating PI3K/Akt pathway, a critical survival pathway in neurons and in most cell types, through heregulin |
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contributes to tumorigenic conversion and that their expression levels may be increased by signaling initiated by TGF-alpha ( |
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ERBB3 signaling may contribute to metastatic progression of melanoma |
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ERBB3 function is an important aspect of ERBB2-mediated breast cancer, prompting the need for a more thorough understanding of ERBB3 expression and dysregulation in breast cancer |
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both ERBB3 and RNF41 are dysregulated post-transcriptionally in tumors |
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functions in part, by modulating the activity of ERBB3 |
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plays an essential role in ERBB2-mediated transformation, tumor progression, and drug resistance |
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regulates the balance of differentiated breast epithelial cell types by regulating their growth and survival through autocrine- and paracrine-signaling mechanisms |
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is catalytically impaired but binds ligand, and its kinase domain allosterically activates its partners |
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high levels of ERBB2, ERBB3 may not only be a target of constitutive phosphorylation and driver for enhanced cancer cell survival |
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both ERBB2 and ERBB3 are essential for normal proliferation of skin keratinocytes, but in contrast to ERBB3, ERBB2 is essential for migration of human keratinocytes |
