| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
|
|
in squamous cell carcinoma of the head and neck, in retinoblastoma, and in cholangiocarcinoma |
| tumoral
|
|
| --over
|
|
|
in lung and colon adenocarcinoma, pituitary tumors and mammary tumors, in colorectal adenomas |
| tumoral
|
|
| --over
|
|
|
correlated with K-RAS mutation in colorectal adenoma in progression |
| constitutional
|
|
| --over
|
|
|
in neurals cell of the myenteric plexus in active inflammatory bowel disease |
| constitutional
|
|
| --over
|
|
|
in amyotrophic lateral sclerosis |
| tumoral
|
|
| --over
|
|
|
in renal call carcinoma |
| constitutional
|
|
|
| loss of function
|
in cardiomyocytes may contribute to heart failure in patients receiving nonsteroidal anti-inflammatory drugs specific for inhibition of PTGS2  |
| tumoral
|
|
| --over
|
|
|
in colorectal cancer (CRC), rendering tumour cells resistant to apoptosis |
| constitutional
|
|
| --over
|
|
|
in the amnion is critical for the production of prostaglandins that induce labour |
| tumoral
|
|
| --low
|
|
|
in squamous cell carcinoma (SCC) (pMID: 23261444) |
| tumoral
|
|
| --over
|
|
|
of CPSF4 and PTGS2 proteins predicted poor prognosis of patients with lung cancers |
