| 1 | PTGS2, PTH, TNFSF11
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| Prostaglandin-mediated inhibition of PTH-stimulated β-catenin signaling in osteoblasts by bone marrow macrophages.
|
| Estus TL, Choudhary S, Pilbeam CC.
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| Bone 85:123-30. doi: 10.1016/j.bone.2016.01.023.
2016
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| 2 | CPSF4, PTGS2
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| Cleavage and polyadenylation specific factor 4 targets NF-κB/cyclooxygenase-2 signaling to promote lung cancer growth and progression.
|
| Yi C, Wang Y, Zhang C, Xuan Y, Zhao S, Liu T, Li W, Liao Y, Feng X, Hao J, Gao Y, Yu W, Chen Y, Zhang C, Guo W, Tang B, Deng W.
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| Cancer Lett 381(1):1-13. doi: 10.1016/j.canlet.2016.07.016. Epub 2016 Jul 20.
2016
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| 3 | CLOCK, PTGS2
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| Circadian CLOCK Mediates Activation of Transforming Growth Factor-β Signaling and Renal Fibrosis through Cyclooxygenase 2.
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| Chen WD, Yeh JK, Peng MT, Shie SS, Lin SL, Yang CH, Chen TH, Hung KC, Wang CC, Hsieh IC, Wen MS, Wang CY.
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| Am J Pathol 185(12):3152-63. doi: 10.1016/j.ajpath.2015.08.003.
2015
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| 4 | FURIN, PTGS2
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| Dysregulation of FURIN by prostaglandin-endoperoxide synthase 2 in lung epithelial NCI-H292 cells.
|
| Brant KA, Leikauf GD.
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| Mol Carcinog 53(3):192-200. doi: 10.1002/mc.21963. Epub 2012 Oct 12.
2014
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| 5 | ADRB1, PTGS2
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| β1-Adrenergic receptor downregulates the expression of cyclooxygenase-2.
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| Brender S, Barki-Harrington L.
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| Biochem Biophys Res Commun 451(2):319-21. doi: 10.1016/j.bbrc.2014.07.123. Epub 2014 Aug 1.
2014
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| 6 | GDF2, PTGS2
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| BMP9 and COX-2 form an important regulatory loop in BMP9-induced osteogenic differentiation of mesenchymal stem cells.
|
| Wang JH, Liu YZ, Yin LJ, Chen L, Huang J, Liu Y, Zhang RX, Zhou LY, Yang QJ, Luo JY, Zuo GW, Deng ZL, He BC.
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| Bone 57(1):311-21. doi: 10.1016/j.bone.2013.08.015. Epub 2013 Aug 24.
2013
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| 7 | PTGS2, RXRA
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| Elevated COX2 expression and PGE2 production by downregulation of RXRα in senescent macrophages.
|
| Chen H, Ma F, Hu X, Jin T, Xiong C, Teng X.
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| Biochem Biophys Res Commun 440(1):157-62. doi: 10.1016/j.bbrc.2013.09.047. Epub 2013 Sep 16.
2013
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| 8 | PTGS2, SNAI1
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| The transcription factor Snail expressed in cutaneous squamous cell carcinoma induces epithelial-mesenchymal transition and down-regulates COX-2.
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| Shimokawa M, Haraguchi M, Kobayashi W, Higashi Y, Matsushita S, Kawai K, Kanekura T, Ozawa M.
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| Biochem Biophys Res Commun 430(3):1078-82. doi: 10.1016/j.bbrc.2012.12.035. Epub 2012 Dec 19.
2013
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| 9 | MAT2A, PTGS2, SETDB1
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| Methionine adenosyltransferase II-dependent histone H3K9 methylation at the COX-2 gene locus.
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| Kera Y, Katoh Y, Ohta M, Matsumoto M, Takano-Yamamoto T, Igarashi K.
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| J Biol Chem 288(19):13592-601. doi: 10.1074/jbc.M112.429738. Epub 2013 Mar 28.
2013
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| 10 | CAV1, DERL1, PTGS2
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| Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex.
|
| Chen SF, Wu CH, Lee YM, Tam K, Tsai YC, Liou JY, Shyue SK.
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| J Biol Chem 288(46):33462-9. doi: 10.1074/jbc.M113.521799. Epub 2013 Oct 2.
2013
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| 11 | AREG, BTC, EREG, PTGS2
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| EGF-like growth factors induce COX-2-derived PGE2 production through ERK1/2 in human granulosa cells.
|
| Fang L, Cheng JC, Chang HM, Sun YP, Leung PC.
|
| J Clin Endocrinol Metab 98(12):4932-41. doi: 10.1210/jc.2013-2662. Epub 2013 Oct 3.
2013
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| 12 | BCL2L14, FAU, PTGS2
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| Ubiquitin-like protein MNSFβ covalently binds to Bcl-G and enhances lipopolysaccharide/interferon γ-induced apoptosis in macrophages.
|
| Watanabe J, Nakagawa M, Watanabe N, Nakamura M.
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| FEBS J 280(5):1281-93. doi: 10.1111/febs.12120. Epub 2013 Feb 11.
2013
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| 13 | PTGES, PTGS2
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| Upregulation of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) in wall of ruptured human cerebral aneurysms: preliminary results.
|
| Hasan D, Hashimoto T, Kung D, Macdonald RL, Winn HR, Heistad D.
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| Stroke 43(7):1964-7. Epub 2012 May 15.
2012
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| 14 | PTGS2, VEGFC
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| Lymphangiogenesis in non-Hodgkin's lymphoma and its correlation with cyclooxygenase-2 and vascular endothelial growth factor-C.
|
| Ma SP, Lin M, Liu HN, Yu JX.
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| Oncol Lett 4(4):695-700. Epub 2012 Jul 23.
2012
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| 15 | ACTA2, PTGS2
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| Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow.
|
| Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E, Brenner DA, Apte RN, Jung S, Lapidot T.
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| Nat Immunol 13(11):1072-82. doi: 10.1038/ni.2408. Epub 2012 Sep 16.
2012
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| 16 | PTGS2, VRK2
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| Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2
|
| Vázquez-Cedeira M, Lazo PA.
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| J Biol Chem. Dec 14;287(51):42739-50. doi: 10.1074/jbc.M112.404285. Epub 2012 Oct 26. 2012
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| 17 | PTGES, PTGS2
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| Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity.
|
| Ikeda-Matsuo Y, Hirayama Y, Ota A, Uematsu S, Akira S, Sasaki Y.
|
| Br J Pharmacol 159(5):1174-86. Epub 2010 Jan 29.
2010
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| 18 | P2RY1, P2RY12, PTGS2, UGT1A6
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| The genetics of antiplatelet drug resistance.
|
| Feher G, Feher A, Pusch G, Lupkovics G, Szapary L, Papp E.
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| Clin Genet 75(1):1-18. Epub 2008 Nov 29. Review.
2009
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| 19 | PTGS2
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| Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for esophageal squmaous cell carcinoma.
|
| Upadhyay R, Jain M, Kumar S, Ghoshal UC, Mittal B.
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| Mutat Res 663(1-2):52-9. Epub 2009 Feb 4.
2009
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| 20 | PTGS2
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| Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function.
|
| Wang D, Patel VV, Ricciotti E, Zhou R, Levin MD, Gao E, Yu Z, Ferrari VA, Lu MM, Xu J, Zhang H, Hui Y, Cheng Y, Petrenko N, Yu Y, FitzGerald GA.
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| Proc Natl Acad Sci U S A 106(18):7548-52. Epub 2009 Apr 17.
2009
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| 21 | PTGS2, STK17B
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| Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer.
|
| Doherty GA, Byrne SM, Austin SC, Scully GM, Sadlier DM, Neilan TG, Kay EW, Murray FE, Fitzgerald DJ.
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| Br J Cancer 101(3):483-91.PMID: 19638987 2009
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| 22 | HBEGF, PTGS2, ST6GALNAC5
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| Genes that mediate breast cancer metastasis to the brain.
|
| Bos PD, Zhang XH, Nadal C, Shu W, Gomis RR, Nguyen DX, Minn AJ, van de Vijver MJ, Gerald WL, Foekens JA, Massagué J.
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| Nature 459(7249):1005-9. Epub 2009 May 6.PMID: 19421193 2009
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| 23 | ELAVL1, PTGS2
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| Expression of embryonic lethal abnormal vision (ELAV)-like protein HuR and cyclooxygenase-2 (COX-2) in Ewing sarcoma.
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| Do SI, Araujo ES, Kalil RK, Bacchini P, Bertoni F, Unni KK, Park YK.
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| Tumori 94(3):347-50.PMID: 18705402 2008
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| 24 | PTGS2
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| Prostaglandin H synthase-2 gene regulation in the amnion at labour: histone acetylation and nuclear factor kappa B binding to the promoter in vivo.
|
| Mitchell CM, Johnson RF, Giles WB, Zakar T.
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| Mol Hum Reprod 14(1):53-9. Epub 2008 Jan 18.PMID: 18204072 2008
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| 25 | LEF1, PTGS2
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| Lef1 regulates COX-2 transcription in chondrocytes.
|
| Yun K, Im SH.
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| Biochem Biophys Res Commun 364(2):270-5. Epub 2007 Oct 11. 2007
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| 26 | PTGS2
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| Cyclooxygenase 2 expression in pterygium.
|
| Chiang CC, Cheng YW, Lin CL, Lee H, Tsai FJ, Tseng SH, Tsai YY.
|
| Mol Vis 13:635-8.
2007
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| 27 | PTGS2, ADIPOQ, PRKAB1
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| Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms.
|
| Shibata R, Sato K, Pimentel DR, Takemura Y, Kihara S, Ohashi K, Funahashi T, Ouchi N, Walsh K.
|
| Nat Med 11(10):1096-103. Epub 2005 Sep 11. 2005
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| 28 | PTGS2
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| Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.
|
| Castellone MD, Teramoto H, Williams BO, Druey KM, Gutkind JS.
|
| Science 310(5753):1504-10. Epub 2005 Nov 17. 2005
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| 29 | PTGS2
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| Prostaglandin E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases.
|
| Rosch S, Ramer R, Brune K, Hinz B.
|
| Biochem Biophys Res Commun 338(2):1171-8. Epub 2005 Oct 21. 2005
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| 30 | NOS2, PTGS2
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| Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2.
|
| Kim SF, Huri DA, Snyder SH.
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| Science 310(5756):1966-70. 2005
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| 31 | PTGS2
|
| Localization of cyclooxygenases-1 and -2, and prostaglandin F synthase in human kidney and renal cell carcinoma.
|
| Sakurai M, Oishi K, Watanabe K.
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| Biochem Biophys Res Commun 338(1):82-6. Epub 2005 Sep 2. 2005
|
| 32 | PTGS1, PTGS2, PTGES
|
| Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney.
|
| Schneider A, Zhang Y, Zhang M, Lu WJ, Rao R, Fan X, Redha R, Davis L, Breyer RM, Harris R, Guan Y, Breyer MD.
|
| Kidney Int 65(4):1205-13. 2004
|
| 33 | PTGS2
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| COX-2 gene promoter haplotypes and prostate cancer risk.
|
| Panguluri RC, Long LO, Chen W, Wang S, Coulibaly A, Ukoli F, Jackson A, Weinrich S, Ahaghotu C, Isaacs W, Kittles RA.
|
| Carcinogenesis 25(6):961-6. Epub 2004 Jan 30. 2004
|
| 34 | PTGS2
|
| Association of a promoter variant in the inducible cyclooxygenase-2 gene (PTGS2) with type 2 diabetes mellitus in Pima Indians.
|
| Konheim YL, Wolford JK.
|
| Hum Genet 113(5):377-81. Epub 2003 Aug 14. 2003
|
| 35 | PTGS2
|
| Cyclooxygenase-2 expression in human pituitary tumors.
|
| Vidal S, Kovacs K, Bell D, Horvath E, Scheithauer BW, Lloyd RV.
|
| Cancer 97(11):2814-21. 2003
|
| 36 | PTGS2
|
| Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy.
|
| Sennlaub F, Valamanesh F, Vazquez-Tello A, El-Asrar AM, Checchin D, Brault S, Gobeil F, Beauchamp MH, Mwaikambo B, Courtois Y, Geboes K, Varma DR, Lachapelle P, Ong H, Behar-Cohen F, Chemtob S.
|
| Circulation 108(2):198-204. Epub 2003 Jun 23. 2003
|
| 37 | PTGS1, PTGS2
|
| Expression and localization of cyclooxygenase-1 and -2 in human sporadic amyotrophic lateral sclerosis.
|
| Maihofner C, Probst-Cousin S, Bergmann M, Neuhuber W, Neundorfer B, Heuss D.
|
| Eur J Neurosci 18(6):1527-34. 2003
|
| 38 | PTGS2
|
| Purification and characterization of a cyclooxygenase-2 and angiogenesis suppressing factor produced by human fibroblasts.
|
| Deng WG, Saunders MA, Gilroy DW, He XZ, Yeh H, Zhu Y, Shtivelband MI, Ruan KH, Wu KK.
|
| FASEB J 16(10):1286-8. Epub 2002 Jun 07. 2002
|
| 39 | PTGS2, ERBB2
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| ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions.
|
| Endo K, Yoon BI, Pairojkul C, Demetris AJ, Sirica AE.
|
| Hepatology 36(2):439-50. 2002
|
| 40 | PTGS2
|
| Neuronal COX-2 expression in human myenteric plexus in active inflammatory bowel disease.
|
| Roberts PJ, Morgan K, Miller R, Hunter JO, Middleton SJ.
|
| Gut 48(4):468-72. 2001
|
| 41 | PTGS2
|
| Cyclooxygenase-2 expression in human gliomas: prognostic significance and molecular correlations.
|
| Shono T, Tofilon PJ, Bruner JM, Owolabi O, Lang FF.
|
| Cancer Res 61(11):4375-81. 2001
|
| 42 | PTGS2
|
| Expression of cyclooxygenase-2 (COX-2) mRNA in human colorectal adenomas.
|
| Hasegawa K, Ichikawa W, Fujita T, Ohno R, Okusa T, Yoshinaga K, Sugihara K.
|
| Eur J Cancer 37(12):1469-74. 2001
|
| 43 | PTGS2
|
| Cox-2 expression in retinoblastoma.
|
| Karim MM, Hayashi Y, Inoue M, Imai Y, Ito H, Yamamoto M.
|
| Am J Ophthalmol 129(3):398-401. 2000
|
| 44 | PTGS2
|
| COX-2 is expressed in human pulmonary, colonic, and mammary tumors.
|
| Soslow RA, Dannenberg AJ, Rush D, Woerner BM, Khan KN, Masferrer J, Koki AT.
|
| Cancer 89(12):2637-45. 2000
|
| 45 | PTGS2
|
| Relationship between cyclooxygenase-2 expression and K-ras gene mutation in colorectal adenomas.
|
| Fujita M, Fukui H, Kusaka T, Morita K, Fujii S, Ueda Y, Chiba T, Sakamoto C, Kawamata H, Fujimori T.
|
| J Gastroenterol Hepatol 15(11):1277-81. 2000
|
| 46 | PTGS2
|
| Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck.
|
| Chan G, et al.
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| Cancer Res 59(5):991-4. 1999
|
| 47 | PTGS2
|
| The early induction of cyclooxygenase 2 associated with neurofibrillary degeneration in brains of patients with Fukuyama-type congenital muscular dystrophy.
|
| Oka A, et al.
|
| Neuropediatrics 30(1):34-7. 1999
|
| 48 | PTGS1, PTGS2
|
| Patterns of cyclooxygenase-1 and -2 expression in human gliomas in vivo.
|
| Deininger MH, Weller M, Streffer J, Mittelbronn M, Meyermann R.
|
| Acta Neuropathol (Berl) 98(3):240-4 1999
|
| 49 | PTGS2
|
| The inducible prostaglandin biosynthetic enzyme, cyclooxygenase 2, is not mutated in patients with attenuated adenomatous polyposis coli.
|
| Spirio LN, et al.
|
| Cancer Res 58 : 4909-4912. 1998
|
| 50 | PLA2G2A, PTGS2
|
| Gene expression of cyclooxygenase-2, group II and cytosolic phospholipase A2 in human colorectal cancer.
|
| Dimberg J, et al.
|
| Anticancer Res 18 : 3283-3287. 1998
|
| 51 | AMBP, APOD, C8G, CRABP1, CRABP2, LCN1, LCN2, OBP2A, OBP2B, ORM1, ORM2, PAEP, PTGS1, PTGS2, RBP1, RBP2, RBP3, RBP4
|
| The lipocalin protein family: structure and function.
|
| Flower DR.
|
| Biochem J 318 ( Pt 1):1-14. Review 1996
|
| 52 | PLA2G4A, PTGS2
|
| Cytosolic phospholipase A2 gene in human and rat : chromosomal localization and polymorphic markers.
|
| Tay A, et al.
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| Genomics 26 : 138-141. 1995
|
| 53 | PTGS2
|
| Assignment of the human prostaglandin-endoperoxide synthase 2 (PTGS2) gene to 1q25 by fluorescence in situ hybridization.
|
| Tay A, et al.
|
| Genomics 23 : 718-719. 1994
|
| 54 | PTGS2
|
| Structure of the human cyclo-oxygenase-2 gene.
|
| Appleby SB, et al.
|
| Biochem J 302 : 723-727. 1994
|
| 55 | PTGS2
|
| Characterization of the genomic structure, chromosomal location and promoter of human prostaglandin H synthase-2 gene.
|
| Tazawa R, et al.
|
| Biochem Biophys Res Commun 203 : 190-199. 1994
|
| 56 | PTGS2
|
| Structure of the human cyclo-oxygenase-2 gene.
|
| Appleby SB, Ristimäki A, Neilson K, Narko K, Hla T.
|
| Biochem J 302 ( Pt 3):723-7.
1994
|
| 57 | PTGS2
|
| Molecular cloning fo human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.
|
| Jones DA, et al.
|
| J Biol Chem 268 : 9049-9054. 1993
|
| 58 | PTGS2
|
| Human cyclooxygenase-2 cDNA.
|
| Hla T, et al.
|
| Proc Natl Acad Sci U S A 89 : 7384-7388. 1992
|