basic FUNCTION
| prostaglandin G/H synthase, potent mediator of inflammation and role for prostanoid signaling in activity dependent plasticity |
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oxidoreductase/electron transporter |
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inducible enzyme that plays an important role in several pathophysiological processes, including inflammation, angiogenesis, and tumorigenesis( may be involved in the regulation of angiogenesis in pituitary tumors) |
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playing an important role in ischemic proliferative retinopathy, as in diabetes |
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stimulates colon cancer cell growth through its heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptor, EP2 |
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catalyzing the crucial step of the production of prostaglandin E2, which is a principal mediator of joint inflammation such as rheumatoid arthritis and osteoarthritis |
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may also play a role in pterygium formation  |
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is transcriptionally active before and after labour  |
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in cardiomyocytes, influences cardiac rhythm and function  |
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with ST6GALNAC5 and HBEGF, are mediators of cancer cell passage through the blood-brain barrier  |
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PTGES and PTGS2 are co-localized and act together to exacerbate stroke injury, by excessive PGE(2) production  |
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plays an important role in GDF2 induced osteogenic differentiation in mesenchymal stem cells  |