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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

FLII

contributors: mct - updated : 10-12-2017

HGNC name	flightless I homolog (Drosophila)
HGNC id	3750

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     constantly, in Smith-Magenis syndrome (SMCR) constitutional     --over   increased in the blistered skin of patients with epidermolysis bullosa (EB) tumoral     --over   negatively regulated MLXIPL mediated transcription in cancer cells

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer skin   targeting FLII may be a potential strategy for reducing the severity of cutaneous squamous cell carcinoma obesity     FLII may serve as a novel therapeutic target in the treatment of adiposity-related metabolic syndromes

ANIMAL & CELL MODELS