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FLASH GENE
Symbol FLII contributors: mct - updated : 10-12-2015
HGNC name flightless I homolog (Drosophila)
HGNC id 3750
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional   deletion    
constantly, in Smith-Magenis syndrome (SMCR)
constitutional     --over  
increased in the blistered skin of patients with epidermolysis bullosa (EB)
tumoral     --over  
negatively regulated MLXIPL mediated transcription in cancer cells
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerskin 
targeting FLII may be a potential strategy for reducing the severity of cutaneous squamous cell carcinoma
obesity  
FLII may serve as a novel therapeutic target in the treatment of adiposity-related metabolic syndromes
ANIMAL & CELL MODELS