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FLASH GENE

Symbol

SLC16A1

contributors: mct - updated : 19-03-2017

HGNC name	solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
HGNC id	10922

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MCTD , HHF7

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   significantly increased in colorectal carcinomas. Gain of membrane expression directly related to the presence of vascular invasion tumoral     --over   in neoplastic lymphocytes 2) tumoral     --over   in glycolytic breast tumors, and high SLC16A1 expression predicts poor prognosis in breast cancer patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer brain   may be a novel therapeutic target for treatment of malignant medulloblastomas cancer     pharmacological inhibition of SLC16A1 and SLC16A4 combined with metformin treatment is a potential cancer therapy cancer brain glioma/neuroblstoma development of therapeutic approaches targeting SLC16A1 may be a promising strategy in glioblastoma treatment

ANIMAL & CELL MODELS