| 1 | SLC16A1, SLC16A4
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| Homology modeling and site-directed mutagenesis identify amino acid residues underlying the substrate selection mechanism of human monocarboxylate transporters 1 (hMCT1) and 4 (hMCT4).
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| Futagi Y, Kobayashi M, Narumi K, Furugen A, Iseki K.
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| Cell Mol Life Sci 76(24):4905-4921. doi: 10.1007/s00018-019-03151-z. Epub 2019 May 17.
2019
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| 2 | SLC16A1, SLC16A4
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| Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells.
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| Benjamin D, Robay D, Hindupur SK, Pohlmann J, Colombi M, El-Shemerly MY, Maira SM, Moroni C, Lane HA, Hall MN.
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| Cell Rep 25(11):3047-3058.e4. doi: 10.1016/j.celrep.2018.11.043.
2018
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| 3 | SLC16A1, TOMM20
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| Mitochondrial and glycolytic metabolic compartmentalization in diffuse large B-cell lymphoma.
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| Gooptu M, Whitaker-Menezes D, Sprandio J, Domingo-Vidal M, Lin Z, Uppal G, Gong J, Fratamico R, Leiby B, Dulau-Florea A, Caro J, Martinez-Outschoorn U.
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| Semin Oncol 44(3):204-217. doi: 10.1053/j.seminoncol.2017.10.002. Epub 2017 Oct 10.
2017
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| 4 | SLC16A1, SLC16A4
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| The flexible cytoplasmic loop 3 contributes to the substrate affinity of human monocarboxylate transporters.
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| Futagi Y, Sasaki S, Kobayashi M, Narumi K, Furugen A, Iseki K.
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| Biochim Biophys Acta Biomembr 1859(10):1790-1795. doi: 10.1016/j.bbamem.2017.05.014. Epub 2017 May 27.
2017
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| 5 | SLC16A1, SLC16A4
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| The metabolic microenvironment of melanomas: Prognostic value of MCT1 and MCT4.
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| Pinheiro C, Miranda-Gonçalves V, Longatto-Filho A, Vicente AL, Berardinelli GN, Scapulatempo-Neto C, Costa RF, Viana CR, Reis RM, Baltazar F, Vazquez VL.
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| Cell Cycle 15(11):1462-70. doi: 10.1080/15384101.2016.1175258. Epub 2016 Apr 22.
2016
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| 6 | SLC16A1
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| MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4.
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| Hong CS, Graham NA, Gu W, Espindola Camacho C, Mah V, Maresh EL, Alavi M, Bagryanova L, Krotee PAL, Gardner BK, Behbahan IS, Horvath S, Chia D, Mellinghoff IK, Hurvitz SA, Dubinett SM, Critchlow SE, Kurdistani SK, Goodglick L, Braas D, Graeber TG, Christofk HR.
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| Cell Rep 14(7):1590-1601. doi: 10.1016/j.celrep.2016.01.057. Epub 2016 Feb 11.
2016
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| 7 | SLC16A1, SLC16A4
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| Prognostic Indications of Elevated MCT4 and CD147 across Cancer Types: A Meta-Analysis.
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| Bovenzi CD, Hamilton J, Tassone P, Johnson J, Cognetti DM, Luginbuhl A, Keane WM, Zhan T, Tuluc M, Bar-Ad V, Martinez-Outschoorn U, Curry JM.
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| Biomed Res Int 2015:242437. doi: 10.1155/2015/242437. Epub 2015 Dec 8. Review.
2015
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| 8 | SLC16A1, SLC16A4
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| Distribution of monocarboxylate transporters in the peripheral nervous system suggests putative roles in lactate shuttling and myelination.
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| Domènech-Estévez E, Baloui H, Repond C, Rosafio K, Médard JJ, Tricaud N, Pellerin L, Chrast R.
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| J Neurosci 35(10):4151-6. doi: 10.1523/JNEUROSCI.3534-14.2015.
2015
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| 9 | BSG, SLC16A1, SLC16A4
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| CD147 required for corneal endothelial lactate transport.
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| Li S, Nguyen TT, Bonanno JA.
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| Invest Ophthalmol Vis Sci 55(7):4673-81. doi: 10.1167/iovs.14-14386.
2014
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| 10 | SLC16A1, SLC16A3, SLC16A7, SLC16A8
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| The SLC16 gene family - structure, role and regulation in health and disease.
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| Halestrap AP.
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| Mol Aspects Med 34(2-3):337-49. doi: 10.1016/j.mam.2012.05.003. Review.
2013
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| 11 | SLC16A1, SLC16A4
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| Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets.
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| Miranda-Gonçalves V, Honavar M, Pinheiro C, Martinho O, Pires MM, Pinheiro C, Cordeiro M, Bebiano G, Costa P, Palmeirim I, Reis RM, Baltazar F.
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| Neuro Oncol 15(2):172-88. doi: 10.1093/neuonc/nos298. Epub 2012 Dec 20.
2013
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| 12 | IL8, SLC16A1
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| Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis.
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| Végran F, Boidot R, Michiels C, Sonveaux P, Feron O.
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| Cancer Res 71(7):2550-60. Epub 2011 Feb 7.
2011
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| 13 | BSG, SLC16A1, SLC16A4
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| CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.
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| Le Floch R, Chiche J, Marchiq I, Naiken T, Ilc K, Murray CM, Critchlow SE, Roux D, Simon MP, Pouysségur J.
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| Proc Natl Acad Sci U S A 108(40):16663-8. doi: 10.1073/pnas.1106123108. Epub 2011 Sep 19. Erratum in: Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20166. 2011
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| 14 | SLC16A1, SLC16A4
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| Monocarboxylate transport in human corneal epithelium and cell lines.
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| Vellonen KS, Häkli M, Merezhinskaya N, Tervo T, Honkakoski P, Urtti A.
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| Eur J Pharm Sci 39(4):241-7. doi: 10.1016/j.ejps.2009.12.006. Epub 2009 Dec 24.
2010
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| 15 | SLC16A1, SLC16A2, SLC16A4
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| Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes.
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| Pérez de Heredia F, Wood IS, Trayhurn P.
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| Pflugers Arch 459(3):509-18. doi: 10.1007/s00424-009-0750-3. Epub 2009 Oct 30.
2010
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| 16 | SLC16A1
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| miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1.
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| Li KK, Pang JC, Ching AK, Wong CK, Kong X, Wang Y, Zhou L, Chen Z, Ng HK.
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| Hum Pathol 40(9):1234-43. Epub 2009 May 7.
2009
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| 17 | SLC16A1
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| PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2.
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| Saksena S, Dwivedi A, Gill RK, Singla A, Alrefai WA, Malakooti J, Ramaswamy K, Dudeja PK.
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| Am J Physiol Gastrointest Liver Physiol 296(2):G275-83. Epub 2008 Nov 25.
2009
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| 18 | SLC16A1
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| Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas.
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| Pinheiro C, Longatto-Filho A, Scapulatempo C, Ferreira L, Martins S, Pellerin L, Rodrigues M, Alves VA, Schmitt F, Baltazar F.
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| Virchows Arch 452(2):139-46. Epub 2008 Jan 10.
2008
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| 19 | HHF7, MCTD, SLC16A1
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| Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic Beta cells.
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| Otonkoski T, Jiao H, Kaminen-Ahola N, Tapia-Paez I, Ullah MS, Parton LE, Schuit F, Quintens R, Sipila I, Mayatepek E, Meissner T, Halestrap AP, Rutter GA, Kere J.
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| Am J Hum Genet 81(3):467-74. Epub 2007 Jul 26. 2007
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| 20 | SLC16A1, SLC16A2, SLC16A4
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| Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice.
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| Pierre K, Parent A, Jayet PY, Halestrap AP, Scherrer U, Pellerin L.
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| J Physiol 583(Pt 2):469-86. Epub 2007 Jun 28.
2007
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| 21 | SLC16A1
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| The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis.
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| Cuff MA, Shirazi-Beechey SP.
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| Biochem Biophys Res Commun 292(4):1048-56. 2002
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| 22 | MCTD, SLC16A1
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| Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport.
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| Merezhinskaya N, Fishbein WN, Davis JI, Foellmer JW.
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| Muscle Nerve 23(1):90-7. 2000
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| 23 | SLC16A1, SLC16A10, SLC16A2, SLC16A3, SLC16A4, SLC16A5, SLC16A6, SLC16A7, SLC16A8
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| The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation.
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| Halestrap AP, Price NT.
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| Biochem J 343 Pt 2:281-99. Review. 1999
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| 24 | SLC16A1
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| cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12.
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| Garcia CK, et al.
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| Genomics 23 : 500-503. 1994
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