basic FUNCTION
| H+ coupled monocarboxylate transporter 1, mediating movement of lactate and pyruvate, branched-chain oxo acids, ketone bodies acetoacetate, beta-hydroxybutyrate and acetate across the colonocytes luminal membranes |
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hypoxia stimulates lactate release and modulates monocarboxylate transporter (SLC16A1, SLC16A2, and SLC16A4) expression in human adipocytes |
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involved in lactate enter in endothelial cells, and stimulatibg an autocrine NFKB/IL8 pathway driving cell migration and tube formation |
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lactate homeostasis participates in the regulation of the Schwann cells (SCs) myelination program and reveal that similar to CNS, PNS axon-glial metabolic interactions are most likely mediated by SLC16A4, SLC16A1 |
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modulates cancer cell pyruvate export and growth of tumors |
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exhibits high-affinity l-lactate transport and broad substrate recognition |
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mediate L-lactate transport, but, also transports L-5-oxoproline (L-OPro), and amino acid residues, M69 and F367, are key molecular elements for the transport of L-OPro |