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FLASH GENE

Symbol

AGRN

contributors: mct/npt/pgu - updated : 22-08-2018

HGNC name	agrin
HGNC id	329

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function formation of senile plaques and neurofibrillary tangles in dementia of Alzheimer type constitutional         accelerating the formation of insoluble protein fibrils in Parkinson's disease constitutional     --low   induced by nerve injury contributes to neuropathic pain

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous pain   acetaminophen analog, promoted agrin upregulation, and may open new approaches for treating not only neuropathic pain, but also epilepsy, tremors, and spasticity

ANIMAL & CELL MODELS