| 1 | AGRN, PRSS12
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| Genes encoding agrin (AGRN) and neurotrypsin (PRSS12) are associated with muscle mass, strength and plasma C-terminal agrin fragment concentration.
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| Pratt J, Whitton L, Ryan A, Juliusdottir T, Dolan J, Conroy J, Narici M, De Vito G, Boreham C.
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| Geroscience Jan 7. doi: 10.1007/s11357-022-00721-1. Epub ahead of print. 2023
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| 2 | AGRN, CLASP2, GSK3B, PHLDB2
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| CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles.
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| Basu S, Sladecek S, Martinez de la Peńa y Valenzuela I, Akaaboune M, Smal I, Martin K, Galjart N, Brenner HR.
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| Mol Biol Cell 26(5):938-51. doi: 10.1091/mbc.E14-06-1158. Epub 2015 Jan 14.
2015
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| 3 | AGRN, MUSK
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| The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses.
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| Tezuka T, Inoue A, Hoshi T, Weatherbee SD, Burgess RW, Ueta R, Yamanashi Y.
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| Proc Natl Acad Sci U S A 111(46):16556-61. doi: 10.1073/pnas.1408409111. Epub 2014 Nov 3.
2014
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| 4 | ACHE, AGRN
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| Acetylcholinesterase and agrin: Different functions, similar expression patterns, multiple roles.
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| Mis K, Matkovic U, Pirkmajer S, Sciancalepore M, Lorenzon P, Mars T, Grubic Z.
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| Chem Biol Interact hem Biol Interact. 2012 Oct 29. doi:pii: S0009-2797(12)00215-3. 10.1016/j.cbi.2012.10.009. [Epub ahead of print]
2012
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| 5 | AGRN, CLASP2
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| Agrin regulates CLASP2-mediated capture of microtubules at the neuromuscular junction synaptic membrane.
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| Schmidt N, Basu S, Sladecek S, Gatti S, van Haren J, Treves S, Pielage J, Galjart N, Brenner HR.
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| J Cell Biol 198(3):421-37. doi: 10.1083/jcb.201111130. Epub 2012 Jul 30.
2012
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| 6 | AGRN, CHRNA1
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| Agrin induces association of Chrna1 mRNA and nicotinic acetylcholine receptor in C2C12 myotubes.
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| Chang YF, Chou HJ, Yen YC, Chang HW, Hong YR, Huang HW, Tseng CN.
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| FEBS Lett 586(19):3111-6. doi: 10.1016/j.febslet.2012.07.068. Epub 2012 Aug 2.
2012
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| 7 | AGRN, LRP4, MUSK
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| Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses.
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| Yumoto N, Kim N, Burden SJ.
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| Nature 489(7416):438-42. doi: 10.1038/nature11348.
2012
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| 8 | AGRN, LRP4, MUSK
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| Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK).
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| Zhang W, Coldefy AS, Hubbard SR, Burden SJ.
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| J Biol Chem 286(47):40624-30. doi: 10.1074/jbc.M111.279307. Epub 2011 Oct 3.
2011
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| 9 | AGRN
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| Agrin downregulation induced by nerve injury contributes to neuropathic pain.
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| Cui JG, Bazan NG.
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| J Neurosci 30(45):15286-97.
2010
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| 10 | AGRN
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| Agrin binds BMP2, BMP4 and TGFbeta1.
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| Bányai L, Sonderegger P, Patthy L.
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| PLoS One 5(5):e10758.
2010
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| 11 | AGRN, DAG1, EGR3
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| α-Dystroglycan is essential for the induction of Egr3, a transcription factor important in muscle spindle formation.
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| Williams S, Jacobson C.
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| Dev Neurobiol 70(7):498-507.
2010
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| 12 | AGRN
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| The process-inducing activity of transmembrane agrin requires follistatin-like domains.
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| Porten E, Seliger B, Schneider VA, Wöll S, Stangel D, Ramseger R, Kröger S.
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| J Biol Chem 285(5):3114-25. Epub 2009 Nov 25.
2010
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| 13 | AGRN, CRK, CRKL, DOK7, MUSK
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| Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L.
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| Hallock PT, Xu CF, Park TJ, Neubert TA, Curran T, Burden SJ.
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| Genes Dev 24(21):2451-61.
2010
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| 14 | AGRN, CMS1E
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| Identification of an agrin mutation that causes congenital myasthenia and affects synapse function.
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| Huzé C, Bauché S, Richard P, Chevessier F, Goillot E, Gaudon K, Ben Ammar A, Chaboud A, Grosjean I, Lecuyer HA, Bernard V, Rouche A, Alexandri N, Kuntzer T, Fardeau M, Fournier E, Brancaccio A, Rüegg MA, Koenig J, Eymard B, Schaeffer L, Hantaď D.
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| Am J Hum Genet 85(2):155-67. Epub 2009 Jul 23.
2009
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| 15 | AGRN
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| Transmembrane agrin regulates dendritic filopodia and synapse formation in mature hippocampal neuron cultures.
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| McCroskery S, Bailey A, Lin L, Daniels MP.
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| Neuroscience 163(1):168-79. Epub 2009 Jun 10.
2009
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| 16 | AGRN
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| Agrin regulation of alpha3 sodium-potassium ATPase activity modulates cardiac myocyte contraction.
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| Hilgenberg LG, Pham B, Ortega M, Walid S, Kemmerly T, O'Dowd DK, Smith MA.
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| J Biol Chem 284(25):16956-65. Epub 2009 Apr 16.
2009
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| 17 | AGRN
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| Transmembrane form agrin-induced process formation requires lipid rafts and the activation of Fyn and MAPK.
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| Ramseger R, White R, Kröger S.
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| J Biol Chem 284(12):7697-705. Epub 2009 Jan 12.
2009
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| 18 | AGRN, NOVA1, NOVA2
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| Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing.
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| Ruggiu M, Herbst R, Kim N, Jevsek M, Fak JJ, Mann MA, Fischbach G, Burden SJ, Darnell RB.
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| Proc Natl Acad Sci U S A 106(9):3513-8. doi: 10.1073/pnas.0813112106. Epub 2009 Feb 12.
2009
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| 19 | AGRN, LRP4, MUSK
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| Lrp4 is a receptor for Agrin and forms a complex with MuSK.
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| Kim N, Stiegler AL, Cameron TO, Hallock PT, Gomez AM, Huang JH, Hubbard SR, Dustin ML, Burden SJ.
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| Cell 135(2):334-42. Epub 2008 Oct 9.
2008
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| 20 | AGRN, LRP4
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| LRP4 serves as a coreceptor of agrin.
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| Zhang B, Luo S, Wang Q, Suzuki T, Xiong WC, Mei L.
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| Neuron 60(2):285-97.
2008
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| 21 | AGRN
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| Agrin and laminin induce acetylcholine receptor clustering by convergent, Rho GTPase-dependent signaling pathways.
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| Weston CA, Teressa G, Weeks BS, Prives J.
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| J Cell Sci 120(Pt 5):868-75. Epub 2007 Feb 13.
2007
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| 22 | AGRN
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| Identification of agrinSN isoform and muscle-specific receptor tyrosine kinase (MuSK) [corrected] in sperm.
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| Kumar P, Ferns MJ, Meizel S.
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| Biochem Biophys Res Commun 342(2):522-8. Epub 2006 Feb 8. Erratum in: Biochem Biophys Res Commun. 2006 May 26;344(1):453. 2006
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| 23 | AGRN, ATP1A3
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| Alpha3Na+/K+-ATPase is a neuronal receptor for agrin.
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| Hilgenberg LG, Su H, Gu H, O'Dowd DK, Smith MA.
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| Cell 125(2):359-69. 2006
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| 24 | DAG1, AGRN, MUSK
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| Activation of muscle-specific receptor tyrosine kinase and binding to dystroglycan are regulated by alternative mRNA splicing of agrin.
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| Scotton P, Bleckmann D, Stebler M, Sciandra F, Brancaccio A, Meier T, Stetefeld J, Ruegg MA.
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| J Biol Chem 281(48):36835-45. Epub 2006 Sep 29. 2006
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| 25 | AGRN
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| Agrin binds alpha-synuclein and modulates alpha-synuclein fibrillation.
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| Liu IH, Uversky VN, Munishkina LA, Fink AL, Halfter W, Cole GJ.
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| Glycobiology 15(12):1320-31. Epub 2005 Jul 21. 2005
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| 26 | AGRN
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| Agrin is a chimeric proteoglycan with the attachment sites for heparan sulfate/chondroitin sulfate located in two multiple serine-glycine clusters.
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| Winzen U, Cole GJ, Halfter W.
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| J Biol Chem 278(32):30106-14. Epub 2003 May 28. 2003
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| 27 | AGRN
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| Agrin plays an organizing role in the formation of sympathetic synapses.
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| Gingras J, Rassadi S, Cooper E, Ferns M.
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| J Cell Biol 158(6):1109-18. Epub 2002 Sep 09. 2002
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| 28 | AGRN
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| Agrin-induced phosphorylation of the acetylcholine receptor regulates cytoskeletal anchoring and clustering.
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| Borges LS, Ferns M.
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| J Cell Biol 153(1):1-12. 2001
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| 29 | AGRN
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| Identification and characterization of 5' extension of mammalian agrin cDNA, the exons and the promoter sequences.
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| Shigemoto K, Kubo S, Maruyama N, Yamada S, Obata K, Kikuchi K, Kondo I.
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| Biochim Biophys Acta 1494(1-2):170-4. 2000
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| 30 | AGRN
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| Agrin is a major heparan sulfate proteoglycan accumulating in Alzheimer's disease brain.
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| Verbeek MM, Otte-Holler I, van den Born J, van den Heuvel LP, David G, Wesseling P, de Waal RM.
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| Am J Pathol 155(6):2115-25. 1999
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| 31 | AGRN, FST, FSTL3, TINAG, TMEFF1, TMEFF2, WFIKKN1
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| Follistatin: a multifunctional regulatory protein.
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| Phillips DJ, de Kretser DM.
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| Front Neuroendocrinol 19(4):287-322. Review. 1998
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| 32 | AGRN
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| Agrin is a heparan sulfate proteoglycan.
|
| Tsen G, et al.
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| J Biol Chem 270 : 3392-3399. 1995
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| 33 | AGRN
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| Structure and chromosomal localization of the mammalian agrin gene.
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| Rupp F, et al.
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| J Neurosci 12 : 3535-3544. 1992
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| 34 | AGRN
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| RNA splicing regulates agrin-mediated acetylcholine receptor clustering activity on cultured myotubes.
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| Ferns M, Hoch W, Campanelli JT, Rupp F, Hall ZW, Scheller RH.
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| Neuron 8(6):1079-86. 1992
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| 35 | AGRN
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| Agrin mediates cell contact-induced acetylcholine receptor clustering.
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| Campanelli JT, Hoch W, Rupp F, Kreiner T, Scheller RH.
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| Cell 67(5):909-16. 1991
|