| SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,lysosome
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| text
| large extracellular matrix protein |
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synaptic basal lamina on the surface of muscle fibers, colocalizing with clustered T cell receptors at the surface of activated T cells |
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isoform SN localized in the posterior post-acrosomal, neck, and flagellar mid-piece regions in sperm |
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transmembrane isoform of agrin (Tm-agrin) is the predominant form expressed in the brain  |
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induces the formation of the dense network of microtubules in the subsynaptic cytoplasm and this, in turn, regulates acetylcholine receptor insertion into the postsynaptic membrane |
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| basic FUNCTION
| motor neuron-derived ligand that stimulates MUSK phosphorylation, play critical roles in synaptic differentiation, as synapses do not form in their absence |
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activating the muscle specific receptor tyrosine kinase (MUSK) which phosphorylates AChRs |
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neuronal aggregating factor inducing the aggregation of acetylcholine receptors and other postsynaptic proteins on muscle fibers |
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playing an organizing role in the formation and/or differentiation of interneuronal, cholinergic synapses |
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playing a key role in the formation and maintenance of the neuromuscular junction |
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inducing the aggregation of signaling proteins and the creation of signaling domains not only in nervous systems but also in immune systems |
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may play an important role in the formation of both senile plaques and neurofibrillary tangles |
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accelerating the formation of protofibrils by alpha-synuclein and decreases the half-time of fibril formation |
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stimulates synaptic differentiation by activating MUSK |
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inducing acetylcholine receptor clustering by convergent, Rho GTPase-dependent signaling pathways |
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possible role as a receptor or coreceptor on neurons ( |
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possible modulation of ATP1A3 that is important in regulating heart function |
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physiological role for Tm-agrin in the maturation of hippocampal neurons involving positive regulation of dendritic filopodia and consequent promotion of synaptogenesis, but also possible role for axonal agrin in synaptogenesis |
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having a critical role for synaptic differentiation ( |
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released by motor neurons, and promotes neuromuscular synapse formation by stimulating MUSK, a receptor tyrosine kinase expressed in skeletal muscle ( |
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major factor mediating the neuronal regulation of postsynaptic structures at the vertebrate neuromuscular junction |
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ACHE is a cholinergic and agrin a synaptogenetic component of the neuromuscular junction |
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common features of ACHE and agrin extend to their capacity to play multiple roles in muscle development |
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AGRN and neurotrypsin (PRSS12) are associated with muscle mass, strength and plasma C-terminal agrin fragment concentration |
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