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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

PSME3

contributors: - updated : 01-03-2006

HGNC name	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
HGNC id	9570

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       highly Digestive intestine large intestine colon   moderately   intestine small intestine     moderately   mouth tongue     highly   mouth tongue     highly Lymphoid/Immune lymph node       moderately   spleen       moderately Nervous brain       moderately Reproductive female system uterus cervix   moderately   male system prostate     moderately Skin/Tegument skin       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , hexamer

HOMOLOGY

interspecies	ortholog to murine Psme3
	ortholog to chicken psme3
	ortholog to zebrafish psme3
	homolog to drosophila reg

Homologene

FAMILY	PA28 family
	proteasome activator subunit (PSME) gene family

CATEGORY

chaperone/stress , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	activator subunit of the proteasome
	implicated in immunoproteasome assembly and required for efficient antigen processin
	enhancing the generation of class I binding peptides by altering the cleavage pattern of the proteasome

CELLULAR PROCESS	protein, degradation
	protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

a component	subunit of the proteasome 26S
	PA28 activator complex

INTERACTION

DNA

RNA

small molecule

protein

NCOA3

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	sera from patients with systemic lupus erythematosus often contain antibodies that react with the Ki antigen
Marker
Therapy target

ANIMAL & CELL MODELS