| basic FUNCTION
| playing a role in the compaction of DNA into nucleosomes |
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basal histone, maybe functioning as a dosage-dependent suppressor of genomic instability and tumors |
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involved in the FA/BRCA pathway, and functionally connected to the FA/BRCA pathway to resolve stalled |
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replication forks and prevent chromosome instability |
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have post-replication repair functions distinct from those of ATM, but likely have independent functions that theoretically could synergize in DNA repair and maintenance of genomic integrity |
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functioning as an active determinant of repair/survival upon dephosphorylation  |
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play a facilitative role in homologous recombination |
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plays an important role in replication fork stability as part of a salvage pathway to reinitiate replication following collapse |
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has important role for effective DSB-dependent activation of ATM-related damage responses via NBS1 |
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role in the TP53/CDKN1A pathway and indicate that it is required for CDKN1A-induced cell cycle arrest after replication stalling |
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required for increasing CDKN1A levels after replication inhibition and that this subsequently results in checkpoint activation and cell cycle arrest |
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participates in the DNA damage response and mediates DNA repair |
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like ATM, is essential for viability in a PARP1-deficient background |
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roles of H2AFX and PARP1, PARP2 in the DNA damage response |
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NHEJ1, ATM and H2AFX all have fundamental roles in processing and joining DNA ends during V(D)J recombination, but these roles have been masked by unanticipated functional redundancies |
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preserves the structural integrity of broken DNA ends in G1-phase lymphocytes, thereby preventing these DNA ends from accessing repair pathways that promote genomic instability |
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maintains the structural integrity of broken DNA ends generated during V(D)J recombination in G1-phase lymphocytes |
