| 1 | H2AFX, PPP2R5E
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| PP2A-B56ϵ complex is involved in dephosphorylation of γ-H2AX in the repair process of CPT-induced DNA double-strand breaks.
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| Li X, Nan A, Xiao Y, Chen Y, Lai Y.
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| Toxicology 331:57-65. doi: 10.1016/j.tox.2015.03.007. Epub 2015 Mar 12.
2015
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| 2 | ATM, H2AFX, NHEJ1
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| ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks.
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| Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW.
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| Nature 469(7329):250-4. Epub 2010 Dec 15.
2011
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| 3 | H2AFX, MDC1, NSD2, TP53BP1
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| MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites.
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| Pei H, Zhang L, Luo K, Qin Y, Chesi M, Fei F, Bergsagel PL, Wang L, You Z, Lou Z.
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| Nature 470(7332):124-8. 2011
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| 4 | H2AFX
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| H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.
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| Helmink BA, Tubbs AT, Dorsett Y, Bednarski JJ, Walker LM, Feng Z, Sharma GG, McKinnon PJ, Zhang J, Bassing CH, Sleckman BP.
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| Nature 469(7329):245-9. Epub 2010 Dec 15. Erratum in: Nature. 2011 Apr 14;472(7342):247.
2011
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| 5 | H2AFX, PPM1D
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| Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition.
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| Macůrek L, Lindqvist A, Voets O, Kool J, Vos HR, Medema RH.
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| Oncogene 29(15):2281-91. Epub 2010 Jan 25.PMID: 20101220 2010
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| 6 | H2AFX, PARP1, TP53BP1
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| Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.
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| Orsburn B, Escudero B, Prakash M, Gesheva S, Liu G, Huso DL, Franco S.
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| Mol Cell Biol 30(10):2341-52. Epub 2010 Mar 15.PMID: 20231360 2010
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| 7 | H2AFX, STK4
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| MST1 promotes apoptosis through phosphorylation of histone H2AX.
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| Wen W, Zhu F, Zhang J, Keum YS, Zykova T, Yao K, Peng C, Zheng D, Cho YY, Ma WY, Bode AM, Dong Z.
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| J Biol Chem 285(50):39108-16. Epub 2010 Oct 4.
2010
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| 8 | H2AFX, PARP1, PARP2
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| Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers.
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| Redon CE, Nakamura AJ, Zhang YW, Ji JJ, Bonner WM, Kinders RJ, Parchment RE, Doroshow JH, Pommier Y.
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| Clin Cancer Res 16(18):4532-42. doi: 10.1158/1078-0432.CCR-10-0523. Epub 2010 Sep 7. Review.
2010
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| 9 | CRB2, H2AFX
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| BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint.
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| Sofueva S, Du LL, Limbo O, Williams JS, Russell P.
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| Mol Cell Biol 30(19):4732-43. doi: 10.1128/MCB.00413-10. Epub 2010 Aug 2.
2010
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| 10 | H2AFX
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| Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions.
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| Cook PJ, Ju BG, Telese F, Wang X, Glass CK, Rosenfeld MG.
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| Nature 458(7238):591-6. Epub 2009 Feb 22.
2009
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| 11 | BAZ1B, H2AFX
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| WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.
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| Xiao A, Li H, Shechter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H, Ishibe-Murakami S, Wang B, Tempst P, Hofmann K, Patel DJ, Elledge SJ, Allis CD.
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| Nature 457(7225):57-62. Epub 2008 Dec 17.
2009
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| 12 | ATR, H2AFX
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| ATR and H2AX cooperate in maintaining genome stability under replication stress.
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| Chanoux RA, Yin B, Urtishak KA, Asare A, Bassing CH, Brown EJ.
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| J Biol Chem 284(9):5994-6003. Epub 2008 Dec 2.
2009
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| 13 | ATM, H2AFX, NBN
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| Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1.
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| Kobayashi J, Tauchi H, Chen B, Bruma S, Tashiro S, Matsuura S, Tanimoto K, Chen DJ, Komatsu K.
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| Biochem Biophys Res Commun 380(4):752-7. Epub 2009 Jan 23.
2009
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| 14 | H2AFX
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| H2AX is required for cell cycle arrest via the p53/p21 pathway.
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| Fragkos M, Jurvansuu J, Beard P.
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| Mol Cell Biol 29(10):2828-40. Epub 2009 Mar 9.
2009
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| 15 | H2AFX
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| Histone H2AX is integral to hypoxia-driven neovascularization.
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| Economopoulou M, Langer HF, Celeste A, Orlova VV, Choi EY, Ma M, Vassilopoulos A, Callen E, Deng C, Bassing CH, Boehm M, Nussenzweig A, Chavakis T.
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| Nat Med 15(5):553-8. Epub 2009 Apr 19.
2009
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| 16 | H2AFX, SMARCB1
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| Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation.
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| Ray A, Mir SN, Wani G, Zhao Q, Battu A, Zhu Q, Wang QE, Wani AA.
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| Mol Cell Biol 29(23):6206-19. Epub 2009 Oct 5.PMID: 19805520 2009
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| 17 | ATM, H2AFX
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| Complementary functions of ATM and H2AX in development and suppression of genomic instability.
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| Zha S, Sekiguchi J, Brush JW, Bassing CH, Alt FW.
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| Proc Natl Acad Sci U S A 105(27):9302-6. Epub 2008 Jul 1. 2008
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| 18 | H2AFX, FANCD2
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| Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability.
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| Bogliolo M, Lyakhovich A, Callen E, Castella M, Cappelli E, Ramirez MJ, Creus A, Marcos R, Kalb R, Neveling K, Schindler D, Surralles J.
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| EMBO J 26(5):1340-51. Epub 2007 Feb 15. 2007
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| 19 | ATM,H2AFX
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| Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes.
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| Tanaka T, Kajstura M, Halicka HD, Traganos F, Darzynkiewicz Z.
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| Cell Prolif 40(1):1-13. 2007
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| 20 | H2AFX
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| Detection of phosphorylated histone H2AX in differentiated cells after X-ray irradiation.
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| Gavrilov BA, Firsanov DV, Vezhenkova IV, Solov'eva LV, Mikhailov VM, Tomilin NB.
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| Dokl Biol Sci 414:239-41. No abstract available. 2007
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| 21 | MCPH1, H2AFX
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| MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage.
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| Wood JL, Singh N, Mer G, Chen J.
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| J Biol Chem 282(48):35416-23. Epub 2007 Oct 9. 2007
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| 22 | H2AFX, KAT5, UBE2N
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| DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics.
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| Ikura T, Tashiro S, Kakino A, Shima H, Jacob N, Amunugama R, Yoder K, Izumi S, Kuraoka I, Tanaka K, Kimura H, Ikura M, Nishikubo S, Ito T, Muto A, Miyagawa K, Takeda S, Fishel R, Igarashi K, Kamiya K.
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| Mol Cell Biol 27(20):7028-40. Epub 2007 Aug 20.PMID: 17709392 2007
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| 23 | H2AFX
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| Oxidative stress induces H2AX phosphorylation in human spermatozoa.
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| Li Z, Yang J, Huang H.
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| FEBS Lett 580(26):6161-8. Epub 2006 Oct 17. 2006
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| 24 | H2AFX
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| H2AX chromatin structures and their response to DNA damage revealed by 4Pi microscopy.
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| Bewersdorf J, Bennett BT, Knight KL.
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| Proc Natl Acad Sci U S A 103(48):18137-42. Epub 2006 Nov 16. 2006
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| 25 | H2AFX,MDC1
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| MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.
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| Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP.
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| Cell 123(7):1213-26. 2005
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| 26 | H2AFX
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| Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors.
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| Bassing CH, Suh H, Ferguson DO, Chua KF, Manis J, Eckersdorff M, Gleason M, Bronson R, Lee C, Alt FW.
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| Cell 114(3):359-70. 2003
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| 27 | H2AFX
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| DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139.
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| Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM.
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| J Biol Chem 273(10):5858-68.PMID: 9488723 1998
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| 28 | H2AFX
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| Structure of the mouse H2A.X gene and physical linkage to the UPS locus on chromosome 9 : assignment of the human H2A.X gene to 11q23 by sequence analysis.
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| Porcher C, et al.
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| Genomics 25 : 312-313. 1995
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| 29 | H2AFX
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| Chromosomal localization of the human histone H2A.X gene to 11q23.2-q23.3 by fluorescence in situ hybridization.
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| Ivanova VS, et al.
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| Hum Genet 94 : 303-306. 1994
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| 30 | H2AFX
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| Characterization of the human histone H2A.X gene.
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| Ivanova VS, et al.
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| J Biol Chem 269 : 24189-24194. 1994
|