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FLASH GENE
Symbol AKR1C1 contributors: mct - updated : 16-10-2018
HGNC name aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
HGNC id 384
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
Homologene
FAMILY aldoketo-reductase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • aldo-ketoreductase, catalyzing detoxification of polycyclic aromatic hydrocarbons
  • AKR1C1, AKR1C2 subfamily genes are stress-inducible and might function as survival factors in keratinocytes
  • AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis
  • crucial role of AKR1C1 in regulating both metastasis and drug resistance
  • not only plays an important role in hormone metabolism but is believed to be involved in carcinogen metabolism
  • plays an important role in the development and progression of Small-cell lung cancer (SCLC)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • a major proinflammatory cytokine, IL1B, can facilitate local progesterone metabolism in a cell type critical for maintaining uterine cervical structure via regulating expression of AKR1C1 and AKR1C2
    • cell & other
    REGULATION
    inhibited by long-chain fatty acids that inhibit AKR1C1, AKR1C2, AKR1C4
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    are responsible for sexual development dysgenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may represent an independent biomarker for assessment of the primary prognosis and therapy of small-cell lung cancer
    • Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    should be a potent molecular target in invasive bladder cancer treatment
    ANIMAL & CELL MODELS