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FLASH GENE
Symbol LAMB3 contributors: mct - updated : 21-09-2011
HGNC name laminin, beta 3
HGNC id 6490
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 17 amino acids signal peptide (1.9 kDa)
  • 4 laminin A/neurexin/sex hormone-binding (LNS) globular domains
  • multiple EGF-like motifs within the N terminal short arm allowing the self assembly of chains through interactions of the most terminal globular domain (VI)
  • a long arm composed of heptad repeats typical of a cell alpha helical coiled-coil protein
    • secondary structure three different polypeptide chains (alpha, beta, gamma)
    conjugated GlycoP
    mono polymer heteromer , trimer
    isoforms Precursor a 1155 amino acids mature peptide (127.6 kDa)
    HOMOLOGY
    interspecies homolog to rattus Lamb3 (82.75 pc)
    homolog to murine Lamb3 (81.68 pc)
    Homologene
    FAMILY
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text basement membrane, extracellular matrix
    basic FUNCTION
  • mediating the attachment, migration and organization of cells into tissues during embryonic development
  • LAMB3, LAMC2, in conjunction with MMP7, play a key role in the progression of biliary tract cancer
  • proper expression of LAMB3 and LAMA5 may regulate appropriate hair morphogenesis
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of cutaneous basement membrane zone
  • subunit of laminin 5
  • laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other its expression was regulated by histone methylation as well as DNA methylation
    ASSOCIATED DISORDERS
    corresponding disease(s) EBJ1B , EBJ2B
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    expressed in non small cell lung cancer (coexpression with LAMC2)
    tumoral     --over  
    of LAMB3 and LAMC2 by promoter demethylation in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • evaluation of LAMB3 and COL7A1 mRNA expression is useful for predicting the malignant properties of esophageal squamous cell carcinoma
    • Therapy target
    ANIMAL & CELL MODELS