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FLASH GENE

Symbol

LAMB3

contributors: mct - updated : 21-09-2011

HGNC name	laminin, beta 3
HGNC id	6490

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	two spliced variants encoding the same product

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000228 24 splicing 4093 variant 1 129 1172 - 1995 7774918 a 17 amino acids signal peptide (1.9 kDa) a 23 exons variant containing exon 2b (shorter than 2a) encoding for the same product as variant 2 NM_001017402 22 splicing 4339 variant 2 129 1172 - 1995 7774918 a 17 amino acids signal peptide (1.9 kDa) a 22 exons variant containing exon 2a (longer than 2b) lacking exon 1 encoding for the same product as variant 1 NM_001127641 23 - 4067 - 1172 - 1995 7774918

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   mouth tongue     highly   mouth       highly Reproductive female system ovary     lowly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining epidermis stratum basale highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 17 amino acids signal peptide (1.9 kDa)
	4 laminin A/neurexin/sex hormone-binding (LNS) globular domains
	multiple EGF-like motifs within the N terminal short arm allowing the self assembly of chains through interactions of the most terminal globular domain (VI)
	a long arm composed of heptad repeats typical of a cell alpha helical coiled-coil protein

secondary structure

three different polypeptide chains (alpha, beta, gamma)

conjugated

GlycoP

mono polymer

heteromer , trimer

isoforms

Precursor

a 1155 amino acids mature peptide (127.6 kDa)

HOMOLOGY

interspecies	homolog to rattus Lamb3 (82.75 pc)
	homolog to murine Lamb3 (81.68 pc)

Homologene

FAMILY

CATEGORY

adhesion , structural protein

SUBCELLULAR LOCALIZATION	extracellular
text	basement membrane, extracellular matrix

basic FUNCTION	mediating the attachment, migration and organization of cells into tissues during embryonic development
	LAMB3, LAMC2, in conjunction with MMP7, play a key role in the progression of biliary tract cancer
	proper expression of LAMB3 and LAMA5 may regulate appropriate hair morphogenesis

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component	constituent of cutaneous basement membrane zone
	subunit of laminin 5
	laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma)

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

its expression was regulated by histone methylation as well as DNA methylation

ASSOCIATED DISORDERS

corresponding disease(s)

EBJ1B , EBJ2B

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   expressed in non small cell lung cancer (coexpression with LAMC2) tumoral     --over   of LAMB3 and LAMC2 by promoter demethylation in gastric cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	evaluation of LAMB3 and COL7A1 mRNA expression is useful for predicting the malignant properties of esophageal squamous cell carcinoma
Therapy target

ANIMAL & CELL MODELS