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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

RAD51

contributors: shn/mct - updated : 25-10-2021

HGNC name	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)
HGNC id	9817

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

FANCR , MMVC2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in breast cancer with poor prognosis tumoral   LOH     in breast cancer tumoral     --over   in pancreatic adenocarcinoma tumoral     --over   in the majority of human cancers

Susceptibility

to breast cancer

Variant & Polymorphism SNP	135G->C, increasing the risk of breast cancer in BRCA2 mutation carriers

Candidate gene	overexpression of RAD51 in tumors can suppresse recombination defects and limits genomic instability during carcinogenic progression
Marker
Therapy target

ANIMAL & CELL MODELS

mice heterozygous for a small deletion in the Rad51 gene are viable and fertile and homozygous Rad51 null mutation can be characterized as a preimplantational lethal mutation