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FLASH GENE
Symbol NOS2 contributors: mct/npt - updated : 10-10-2018
HGNC name nitric oxide synthase 2, inducible
HGNC id 7873
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in astrocytes in the optic nerve head and lamina cribosa of glaucomatous eyes (neurotoxic effect)
tumoral     --over  
of NOS2 expression in borderline and malignant epithelial ovarian tumours indicates its involvement in the development and progression of epithelial ovarian cancer (EOC), and its increased expression in less differentiated cancers suggests their association with poor prognosis in this category of tumours
tumoral     --over  
in pancreatic ductal adenocarcinoma (PDAC)
Susceptibility
  • cerebral malaria and severe malarial anemia
  • to multiple sclerosis
  • to pulmonary tuberculosis
    • Variant & Polymorphism SNP
  • promoter C1173T protecting against severe malaria
  • allele 1659 T marker of cerebral malaria
  • variant increasing the risk of multiple sclerosis
  • variants may contribute to TB susceptibility, particularly in individuals of African descent, and may act synergistically with SNPs in TLR4 and IFNGR1 (NOS2A rs2248814 and IFNGR1 rs1327474 and NOS2A rs944722 and IFNGR1 rs1327474 )(Velez 2009)
    • Candidate gene
  • allele sharing with NOS2A and other markers of chromosome 17 (D17S949, D17S799)
  • candidate for MS susceptibility
    • Marker
  • potential relevance of NOS2 as a prognostic factor for glioma malignancy and recurrence
  • NOS2 is a predictor of prognosis in early stage, resected PDAC patients
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivepancreas
    targeting NOS2 may have potential therapeutic value in pancreatic ductal adenocarcinoma
    cancerangiogenesis 
    Therapeutic manipulation of iNOS levels may remove a critical cytoprotective mechanism of importance in tumour angiogenesis
    ANIMAL & CELL MODELS