| 1 | NOS2
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| iNOS inhibits hair regeneration in obese diabetic (ob/ob) mice.
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| Sasaki M, Shinozaki S, Morinaga H, Kaneki M, Nishimura E, Shimokado K.
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| Biochem Biophys Res Commun 501(4):893-897. doi: 10.1016/j.bbrc.2018.05.071. Epub 2018 May 18.
2018
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| 2 | FYN, NOS2
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| Tyrosine kinase Fyn regulates iNOS expression in LPS-stimulated astrocytes via modulation of ERK phosphorylation.
|
| Ko HM, Lee SH, Bang M, Kim KC, Jeon SJ, Park YM, Han SH, Kim HY, Lee J, Shin CY.
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| Biochem Biophys Res Commun 495(1):1214-1220. doi: 10.1016/j.bbrc.2017.11.143. Epub 2017 Nov 26.
2018
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| 3 | KLF4, NOS2
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| Krüppel-like factor 4 regulates the expression of inducible nitric oxide synthase induced by TNF-α in human fibroblast-like synoviocyte MH7A cells.
|
| Mo X, Chen J, Wang X, Pan Z, Ke Y, Zhou Z, Xie J, Lv G, Luo X.
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| Mol Cell Biochem 438(1-2):77-84. doi: 10.1007/s11010-017-3115-9. Epub 2017 Jul 25.
2018
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| 4 | NOS2, SPSB1, SPSB2
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| Anti-Infective Peptides to Enhance the Host Innate Response: Design, Development and Delivery.
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| Norton RS.
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| Protein Pept Lett. ;25(12):1101-1107. doi: 10.2174/0929866525666181101104945 2018
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| 5 | KLF5, NOS2
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| iNOS-derived peroxynitrite mediates high glucose-induced inflammatory gene expression in vascular smooth muscle cells through promoting KLF5 expression and nitration.
|
| Zhang ML, Zheng B, Tong F, Yang Z, Wang ZB, Yang BM, Sun Y, Zhang XH, Zhao YL, Wen JK.
|
| Biochim Biophys Acta Mol Basis Dis 1863(11):2821-2834. doi: 10.1016/j.bbadis.2017.07.004. Epub 2017 Jul 12.
2017
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| 6 | NOS2
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| NOS2 expression in glioma cell lines and glioma primary cell cultures: correlation with neurosphere generation and SOX-2 expression.
|
| Palumbo P, Miconi G, Cinque B, Lombardi F, La Torre C, Dehcordi SR, Galzio R, Cimini A, Giordano A, Cifone MG.
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| Oncotarget 8(15):25582-25598. doi: 10.18632/oncotarget.16106.
2017
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| 7 | IL33, NOS2
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| The role and prognostic value of inducible nitric oxide synthase (iNOS) and interleukin-33 (IL-33) in serous and mucinous epithelial ovarian tumours.
|
| Saied EM, El-Etreby NM.
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| Ann Diagn Pathol 27:62-68. doi: 10.1016/j.anndiagpath.2017.01.006. Epub 2017 Jan 22.
2017
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| 8 | CASP1, NOS2, PARP1
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| Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage.
|
| Buzzo CL, Medina T, Branco LM, Lage SL, Ferreira LC, Amarante-Mendes GP, Hottiger MO, De Carvalho DD, Bortoluci KR.
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| Sci Rep 7:41686. doi: 10.1038/srep41686.
2017
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| 9 | NOS2
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| Inducible Nitric Oxide Synthase (iNOS) Is a Novel Negative Regulator of Hematopoietic Stem/Progenitor Cell Trafficking.
|
| Adamiak M, Abdelbaset-Ismail A, Moore JB 4th, Zhao J, Abdel-Latif A, Wysoczynski M, Ratajczak MZ.
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| Stem Cell Rev 13(1):92-103. doi: 10.1007/s12015-016-9693-1.
2017
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| 10 | NOS2
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| Nitric Oxide Synthase 2 Improves Proliferation and Glycolysis of Peripheral γδ T Cells.
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| Douguet L, Cherfils-Vicini J, Bod L, Lengagne R, Gilson E, Prévost-Blondel A.
|
| PLoS One 11(11):e0165639. doi: 10.1371/journal.pone.0165639. eCollection 2016.
2016
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| 11 | NOS2, RING1
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| Transdifferentiation Requires iNOS Activation: Role of RING1A S-Nitrosylation.
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| Meng S, Zhou G, Gu Q, Chanda PK, Ospino F, Cooke JP.
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| Circ Res 119(9):e129-e138. Epub 2016 Sep 13.
2016
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| 12 | NOS2
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| Inducible nitric oxide synthase enhances disease aggressiveness in pancreatic cancer.
|
| Wang J, He P, Gaida M, Yang S, Schetter AJ, Gaedcke J, Ghadimi BM, Ried T, Yfantis H, Lee D, Weiss JM, Stauffer J, Hanna N, Alexander HR, Hussain SP.
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| Oncotarget 7(33):52993-53004. doi: 10.18632/oncotarget.10323.
2016
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| 13 | EZH2, NOS2
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| Epigenetic suppression of iNOS expression in human endothelial cells: A potential role of Ezh2-mediated H3K27me3.
|
| Dreger H, Ludwig A, Weller A, Baumann G, Stangl V, Stangl K.
|
| Genomics 107(4):145-9. doi: 10.1016/j.ygeno.2016.02.002. Epub 2016 Feb 4.
2016
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| 14 | EP300, NOS2
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| Up-Regulation of Human Inducible Nitric Oxide Synthase by p300 Transcriptional Complex.
|
| Guo Z, Zheng L, Liao X, Geller D.
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| PLoS One 11(1):e0146640. doi: 10.1371/journal.pone.0146640. eCollection 2016.
2016
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| 15 | NOS2
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| Cellular Protective Mechanisms Of Inducible Nitric Oxide Synthase.
|
| Billiar TR.
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| Redox Biol 5:418. doi: 10.1016/j.redox.2015.09.026. Epub 2015 Dec 30.
2015
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| 16 | NOS1, NOS2, NOS3
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| The dual role of iNOS in cancer.
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| Vannini F, Kashfi K, Nath N.
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| Redox Biol 6:334-43. doi: 10.1016/j.redox.2015.08.009. Epub 2015 Aug 24. Review.
2015
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| 17 | NOS2
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| The role of iNOS in cholesterol-induced liver fibrosis.
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| Anavi S, Eisenberg-Bord M, Hahn-Obercyger M, Genin O, Pines M, Tirosh O.
|
| Lab Invest 95(8):914-24. doi: 10.1038/labinvest.2015.67. Epub 2015 Jun 22.
2015
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| 18 | MMP12, NOS2
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| Macrophage metalloelastase (MMP12) regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase.
|
| Lee JT, Pamir N, Liu NC, Kirk EA, Averill MM, Becker L, Larson I, Hagman DK, Foster-Schubert KE, van Yserloo B, Bornfeldt KE, LeBoeuf RC, Kratz M, Heinecke JW.
|
| Endocrinology 155(9):3409-20. doi: 10.1210/en.2014-1037. Epub 2014 Jun 10.
2014
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| 19 | MAPK14, NOS2
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| IGF-1 induces iNOS expression via the p38 MAPK signal pathway in the anti-apoptotic process in pulmonary artery smooth muscle cells during PAH.
|
| Jin C, Guo J, Qiu X, Ma K, Xiang M, Zhu X, Guo J.
|
| J Recept Signal Transduct Res 34(4):325-31. doi: 10.3109/10799893.2014.903417. Epub 2014 Mar 27.
2014
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| 20 | NOS2
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| NOS2 expression is restricted to neurons in the healthy brain but is triggered in microglia upon inflammation.
|
| Béchade C, Colasse S, Diana MA, Rouault M, Bessis A.
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| Glia 62(6):956-63. doi: 10.1002/glia.22652. Epub 2014 Feb 25.
2014
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| 21 | NOS2
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| Epigenetic silencing of the human NOS2 gene: rethinking the role of nitric oxide in human macrophage inflammatory responses.
|
| Gross TJ, Kremens K, Powers LS, Brink B, Knutson T, Domann FE, Philibert RA, Milhem MM, Monick MM.
|
| J Immunol 192(5):2326-38. doi: 10.4049/jimmunol.1301758. Epub 2014 Jan 29.
2014
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| 22 | NOS2
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| Inducible nitric oxide synthase is a major intermediate in signaling pathways for the survival of plasma cells.
|
| Saini AS, Shenoy GN, Rath S, Bal V, George A.
|
| Nat Immunol 15(3):275-82. doi: 10.1038/ni.2806. Epub 2014 Jan 19. Erratum in: Nat Immunol. 2015 Feb;16(2):214.
2014
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| 23 | IRF1, NOS2
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| Interferon regulatory factor 1 is required for cardiac remodeling in response to pressure overload.
|
| Jiang DS, Li L, Huang L, Gong J, Xia H, Liu X, Wan N, Wei X, Zhu X, Chen Y, Chen X, Zhang XD, Li H.
|
| Hypertension 64(1):77-86. doi: 10.1161/HYPERTENSIONAHA.114.03229. Epub 2014 Apr 14.
2014
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| 24 | NOS2
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| ER stress upregulated PGE₂/IFNγ-induced IL-6 expression and down-regulated iNOS expression in glial cells.
|
| Hosoi T, Honda M, Oba T, Ozawa K.
|
| Sci Rep 3:3388. doi: 10.1038/srep03388.
2013
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| 25 | NOS2, RELA, STAT1
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| Regulation of iNOS gene transcription by IL-1β and IFN-γ requires a coactivator exchange mechanism.
|
| Burke SJ, Updegraff BL, Bellich RM, Goff MR, Lu D, Minkin SC Jr, Karlstad MD, Collier JJ.
|
| Mol Endocrinol 27(10):1724-42. doi: 10.1210/me.2013-1159. Epub 2013 Sep 6.
2013
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| 26 | KLF6, NOS2
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| KLF6 and iNOS regulates apoptosis during respiratory syncytial virus infection.
|
| Mgbemena V, Segovia J, Chang TH, Bose S.
|
| Cell Immunol 283(1-2):1-7. doi: 10.1016/j.cellimm.2013.06.002. Epub 2013 Jun 18.
2013
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| 27 | NOS2
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| Positive feedback regulation of human inducible nitric-oxide synthase expression by Ras protein S-nitrosylation.
|
| Lee M, Choy JC.
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| J Biol Chem 288(22):15677-86. doi: 10.1074/jbc.M113.475319. Epub 2013 Apr 18.
2013
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| 28 | EIF4E, NOS2, XPO1
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| Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport.
|
| Bollmann F, Fechir K, Nowag S, Koch K, Art J, Kleinert H, Pautz A.
|
| Nitric Oxide 30:49-59. doi: 10.1016/j.niox.2013.02.083. Epub 2013 Mar 5.
2013
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| 29 | NOS2, POU2F1
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| Oct-1 cooperates with the TATA binding initiation complex to control rapid transcription of human iNOS.
|
| Reveneau S, Petrakis TG, Goldring CE, Chantôme A, Jeannin JF, Pance A.
|
| Cell Mol Life Sci 69(15):2609-19. doi: 10.1007/s00018-012-0939-z. Epub 2012 Feb 19.
2012
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| 30 | NOS2
|
| The circadian deadenylase Nocturnin is necessary for stabilization of the iNOS mRNA in mice.
|
| Niu S, Shingle DL, Garbarino-Pico E, Kojima S, Gilbert M, Green CB.
|
| PLoS One 6(11):e26954. doi: 10.1371/journal.pone.0026954. Epub 2011 Nov 2.
2011
|
| 31 | NOS2, SPSB1, SPSB2, SPSB4
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| Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins.
|
| Nishiya T, Matsumoto K, Maekawa S, Kajita E, Horinouchi T, Fujimuro M, Ogasawara K, Uehara T, Miwa S.
|
| J Biol Chem. Mar 18;286(11):9009-19. doi: 10.1074/jbc.M110.190678. Epub 2011 Jan 3. 2011
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| 32 | NOS2
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| Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes.
|
| Levesque MC, Hobbs MR, O'Loughlin CW, Chancellor JA, Chen Y, Tkachuk AN, Booth J, Patch KB, Allgood S, Pole AR, Fernandez CA, Mwaikambo ED, Mutabingwa TK, Fried M, Sorensen B, Duffy PE, Granger DL, Anstey NM, Weinberg JB.
|
| Hum Genet 127(2):163-82. Epub 2009 Oct 27.PMID: 19859740 2010
|
| 33 | IDO1, NOS2
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| Ido brings down the pressure in systemic inflammation.
|
| Hofmann F.
|
| Nat Med 16(3):265-7. No abstract available. 2010
|
| 34 | NOS2, XBP1
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| XBP1U inhibits the XBP1S-mediated upregulation of the iNOS gene expression in mammalian ER stress response.
|
| Guo F, Lin EA, Liu P, Lin J, Liu C.
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| Cell Signal 22(12):1818-28. Epub 2010 Jul 15.
2010
|
| 35 | ADRM1, NOS2, TP63
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| Phosphorylated TP63 induces transcription of RPN13, leading to NOS2 protein degradation.
|
| Huang Y, Ratovitski EA.
|
| J Biol Chem 285(53):41422-31. doi: 10.1074/jbc.M110.158642. Epub 2010 Oct 19.
2010
|
| 36 | IFNGR1, NOS2, TLR4
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| NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans.
|
| Velez DR, Hulme WF, Myers JL, Weinberg JB, Levesque MC, Stryjewski ME, Abbate E, Estevan R, Patillo SG, Gilbert JR, Hamilton CD, Scott WK.
|
| Hum Genet 126(5):643-53. Epub 2009 Jul 3.PMID: 19575238 2009
|
| 37 | NOS2
|
| Novel noncoding antisense RNA transcribed from human anti-NOS2A locus is differentially regulated during neuronal differentiation of embryonic stem cells.
|
| Korneev SA, Korneeva EI, Lagarkova MA, Kiselev SL, Critchley G, O'Shea M.
|
| RNA 14(10):2030-7.
2008
|
| 38 | HMGA1, NOS2
|
| High mobility group A1 protein mediates human nitric oxide synthase 2 gene expression.
|
| Takamiya R, Baron RM, Yet SF, Layne MD, Perrella MA.
|
| FEBS Lett 582(5):810-4. Epub 2008 Feb 13.
2008
|
| 39 | NOS2
|
| An investigation of NOS2A promoter polymorphisms in Australian multiple sclerosis patients.
|
| Bugeja MJ, Booth DR, Bennetts BH, Heard RN, Burgner D, Stewart GJ.
|
| Eur J Hum Genet 13(7):815-22. 2005
|
| 40 | NOS2, PTGS2
|
| Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2.
|
| Kim SF, Huri DA, Snyder SH.
|
| Science 310(5756):1966-70. 2005
|
| 41 | NOS2
|
| Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis.
|
| Barcellos LF, Begovich AB, Reynolds RL, Caillier SJ, Brassat D, Schmidt S, Grams SE, Walker K, Steiner LL, Cree BA, Stillman A, Lincoln RR, Pericak-Vance MA, Haines JL, Erlich HA, Hauser SL, Oksenberg JR.
|
| Ann Neurol 55(6):793-800. 2004
|
| 42 | CEBPB, NOS2
|
| A critical role for C/EBPbeta binding to the AABS promoter response element in the human iNOS gene.
|
| Guo Z, Shao L, Feng X, Reid K, Marderstein E, Nakao A, Geller DA.
|
| FASEB J 17(12):1718-20. Epub 2003 Jul 3. 2003
|
| 43 | ELK3, NOS2
|
| Elk-3 is a transcriptional repressor of nitric-oxide synthase 2.
|
| Chen YH, Layne MD, Chung SW, Ejima K, Baron RM, Yet SF, Perrella MA.
|
| J Biol Chem 278(41):39572-7. Epub 2003 Jul 31. 2003
|
| 44 | NOS2
|
| A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children.
|
| Hobbs MR, Udhayakumar V, Levesque MC, Booth J, Roberts JM, Tkachuk AN, Pole A, Coon H, Kariuki S, Nahlen BL, Mwaikambo ED, Lal AL, Granger DL, Anstey NM, Weinberg JB.
|
| Lancet 360(9344):1468-75. 2002
|
| 45 | NOS2
|
| Chromosome 17 and the inducible nitric oxide synthase gene in human essential hypertension.
|
| Rutherford S, Johnson MP, Curtain RP, Griffiths LR.
|
| Hum Genet 109(4):408-15. 2001
|
| 46 | NOS2
|
| Identification of residues critical for enzymatic activity in the domain encoded by exons 8 and 9 of the human inducible nitric oxide synthase.
|
| Eissa NT, Haggerty CM, Palmer CD, Patton W, Moss J.
|
| Am J Respir Cell Mol Biol 24(5):616-20. 2001
|
| 47 | ADRA2A, ADRB1, AGTR1, CAFG, CD36, CETP, CSF1, CSF2, CYP11B2, ECE1, EDN1, EDNRA, EDNRB, EGR1, F2R, FGA, FGB, FHBL1, HGF, ICAM1, IGF1, IL1A, IL6, LPA, MGP, MSR1, MTTP, NOS2, NOS3, PDGFA, PDGFRA, SELP, TGFB1, TNF, VCAM1, VDR
|
| Sequence diversity in 36 candidate genes for cardiovascular disorders.
|
| Cambien F, Poirier O, Nicaud V, Herrmann SM, Mallet C, Ricard S, Behague I, Hallet V, Blanc H, Loukaci V, Thillet J, Evans A, Ruidavets JB, Arveiler D, Luc G, Tiret L.
|
| Am J Hum Genet 65(1):183-91. 1999
|
| 48 | NOS2
|
| Nitric-oxide synthase and neurodegeneration/neuroprotection.
|
| Kaufman PL.
|
| Proc Natl Acad Sci U S A 96(17):9455-6. Review. No abstract available 1999
|
| 49 | NOS2
|
| A bi-allelic tetranucleotide repeat in the promoter of the human inducible nitric oxide synthase gene.
|
| Bellamy R, Hill AV.
|
| Clin Genet 52(3):192-3. No abstract available. 1997
|
| 50 | NOS1, NOS2, NOS2B, NOS2C, NOS3
|
| Nitric oxide synthases: which, where, how, and why?
|
| Michel T, Feron O.
|
| J Clin Invest 100(9):2146-52. 1997
|
| 51 | NOS2, NOS2B, NOS2C
|
| Three members of the nitric oxide synthase II gene family (NOS2A, NOS2B,and NOS2C) colocalize to human chromosome 17.
|
| Bloch KD, et al.
|
| Genomics 27 : 526-530. 1995
|
| 52 | NOS2
|
| Localization of the human gene for inducible nitric oxide synthase (NOS2) to chromosome 17q11.2-q12.
|
| Marsden PA, et al.
|
| Genomics 19 : 183-185. 1994
|
| 53 | NOS2
|
| Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene.
|
| Chartrain NA, et al.
|
| J Biol Chem 269 : 6765-6772. 1994
|
| 54 | NOS2, NOS3
|
| Mapping of the genes encoding human inducible and endothelial nitric oxide synthase (NOS2 and NOS3) to the pericentric region of chromosome 17 and to chromosome 7, respectively.
|
| Xu W, et al.
|
| Genomics 21 : 419-422. 1994
|
| 55 | NOS1, NOS2, NOS3
|
| Nitric oxide synthases : roles, tolls, and controls.
|
| Nathan C, et al.
|
| Cell 78 : 915-918. 1994
|
| 56 | NOS2
|
| Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.
|
| Charles IG, et al.
|
| Proc Natl Acad Sci U S A 90 : 11419-11423. 1993
|