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FLASH GENE

Symbol

CDK4

contributors: mct/ - updated : 12-02-2019

HGNC name	cyclin-dependent kinase 4
HGNC id	1773

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CMM3

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     in malignant glioblastoma, anaplastic astrocytoma, in diffuse large B cell lymphoma, osteosarcoma with OS9, SAS and PRIM1 and in sporadic breast carcinoma constitutional     --low   in insulin deficient diabete

Susceptibility

predisposing to familial melanoma by inducing abnormal repair of ultraviolet

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Cdk4-deficient mice display beta-cell hypoplasia and develop diabetes, whereas beta-cell hyperplasia is observed in mice expressing an active Cdk4R24C kinase