| 1 | CDK4, CDK6, TFE3, TFEB
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| CDK4/6 regulate lysosome biogenesis through TFEB/TFE3. 2020 PMID:
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| Yin Q, Jian Y, Xu M, Huang X, Wang N, Liu Z, Li Q, Li J, Zhou H, Xu L, Wang Y, Yang C.
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| J Cell Biol. Aug 3;219(8):e201911036. doi: 10.1083/jcb.201911036. 2020
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| 2 | CDK4, CDK6, RPS14
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| Ribosomal Proteins Control Tumor Suppressor Pathways in Response to Nucleolar Stress
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| Lessard F, Brakier-Gingras L, Ferbeyre G.
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| Bioessays. Mar;41(3):e1800183. doi: 10.1002/bies.201800183. Epub 2019 Feb 1. 2019
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| 3 | CCND1, CDK4, SHCBP1
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| SHCBP1 is a novel target and exhibits tumor‑promoting effects in gastric cancer.
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| Dong YD, Yuan YL, Yu HB, Tian GJ, Li DY.
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| Oncol Rep Mar;41(3):1649-1657. doi: 10.3892/or.2018.6952. Epub 2018 Dec 21 2018
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| 4 | CCND1, CCNE1, CDK2, CDK4, CIAPIN1
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| The study on expression of CIAPIN1 interfering hepatocellular carcinoma cell proliferation and its mechanisms.
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| Huang Z, Su GF, Hu WJ, Bi XX, Zhang L, Wan G.
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| Eur Rev Med Pharmacol Sci 21(13):3054-3060.
2017
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| 5 | CDK4, CDK6
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| CDK4-CDK6 inhibitors induce autophagy-mediated degradation of DNMT1 and facilitate the senescence antitumor response.
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| Bourdeau V, Ferbeyre G.
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| Autophagy utophagy. 2016 Aug 17:1-2. [Epub ahead of print]
2016
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| 6 | CDK4, LAT2, RUNX1T1
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| Runx1t1 (Runt-related transcription factor 1; translocated to, 1) epigenetically regulates the proliferation and nitric oxide production of microglia.
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| Baby N, Li Y, Ling EA, Lu J, Dheen ST.
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| PLoS One 9(2):e89326. doi: 10.1371/journal.pone.0089326. eCollection 2014.
2014
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| 7 | CDK4, CDK6
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| Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis.
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| Rodríguez-Díez E, Quereda V, Bellutti F, Prchal-Murphy M, Partida D, Eguren M, Kollmann K, Gómez de Cedrón M, Dubus P, Cañamero M, Martínez D, Sexl V, Malumbres M.
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| Blood 124(15):2380-90. doi: 10.1182/blood-2014-02-555292. Epub 2014 Aug 25.
2014
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| 8 | CCND1, CDK4, STK38, STK38L
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| Cyclin D1 promotes cell cycle progression through enhancing NDR1/2 kinase activity independent of cyclin-dependent kinase 4.
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| Du Z, Tong X, Ye X.
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| J Biol Chem 288(37):26678-87. doi: 10.1074/jbc.M113.466433. Epub 2013 Jul 29.
2013
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| 9 | CDK1, CDK4, CDK5, UCHL1
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| Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity.
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| Kabuta T, Mitsui T, Takahashi M, Fujiwara Y, Kabuta C, Konya C, Tsuchiya Y, Hatanaka Y, Uchida K, Hohjoh H, Wada K.
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| J Biol Chem 288(18):12615-26. doi: 10.1074/jbc.M112.435701. Epub 2013 Mar 29.
2013
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| 10 | CCND1, CDK4, YY1
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| Yin Yang-1 inhibits tumor cell growth and inhibits p21WAF1/Cip1 complex formation with cdk4 and cyclin D1.
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| Ishii H, Hulett MD, Li JM, Santiago FS, Parish CR, Khachigian LM.
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| Int J Oncol 40(5):1575-80. doi: 10.3892/ijo.2012.1362. Epub 2012 Feb 9.
2012
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| 11 | CCND1, CDK4
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| Cyclin D1 and cdk4 mediate development of neurologically destructive oligodendroglioma.
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| Ciznadija D, Liu Y, Pyonteck SM, Holland EC, Koff A.
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| Cancer Res 71(19):6174-83. doi: 10.1158/0008-5472.CAN-11-1031. Epub 2011 Aug 15.
2011
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| 12 | CDK4, MDM2
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| Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma.
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| Mejia-Guerrero S, Quejada M, Gokgoz N, Gill M, Parkes RK, Wunder JS, Andrulis IL.
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| Genes Chromosomes Cancer 49(6):518-25.PMID: 20196171 2010
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| 13 | CDK4
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| Role of Cdk4 in lymphocyte function and allergen response.
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| Chow YH, Zhu XD, Liu L, Schwartz BR, Huang XZ, Harlan JM, Schnapp LM.
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| Cell Cycle 9(24):4922-30. Epub 2010 Dec 15.
2010
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| 14 | CDK4
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| Cdk4 regulates recruitment of quiescent beta-cells and ductal epithelial progenitors to reconstitute beta-cell mass.
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| Lee JH, Jo J, Hardikar AA, Periwal V, Rane SG.
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| PLoS One 5(1):e8653. doi: 10.1371/journal.pone.0008653.
2010
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| 15 | CDK2, CDK4, NPM2
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| Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells.
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| Adon AM, Zeng X, Harrison MK, Sannem S, Kiyokawa H, Kaldis P, Saavedra HI.
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| Mol Cell Biol 30(3):694-710. doi: 10.1128/MCB.00253-09. Epub 2009 Nov 23.
2010
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| 16 | CDK4
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| Crystal structure of human CDK4 in complex with a D-type cyclin.
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| Day PJ, Cleasby A, Tickle IJ, O'Reilly M, Coyle JE, Holding FP, McMenamin RL, Yon J, Chopra R, Lengauer C, Jhoti H.
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| Proc Natl Acad Sci U S A 106(11):4166-70. Epub 2009 Feb 23.
2009
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| 17 | CDK4
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| The structure of CDK4/cyclin D3 has implications for models of CDK activation.
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| Takaki T, Echalier A, Brown NR, Hunt T, Endicott JA, Noble ME.
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| Proc Natl Acad Sci U S A 106(11):4171-6. Epub 2009 Feb 23.
2009
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| 18 | ASIP, CDK4, CDKN2A, CMM1, CMM2, CMM20, CMM3, CMM4, MC1R, TYR, TYRP1
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| Genetic risk factors for melanoma.
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| Meyle KD, Guldberg P.
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| Hum Genet 126(4):499-510. Epub 2009 Jul 8. Review.
2009
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| 19 | CDK4
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| Migratory localization of cyclin D2-Cdk4 complex suggests a spatial regulation of the G1-S transition.
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| Wang Z, Xie Y, Zhang L, Zhang H, An X, Wang T, Meng A.
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| Cell Struct Funct 33(2):171-83. Epub 2008 Oct 1.
2008
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| 20 | PPP3CA, CDK4
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| Mitotic regulation of CDK4 by the serine/threonine phosphatase, calcineurin.
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| Chow R, Olesen J, Onyskiw C, Baksh S.
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| Biochem Biophys Res Commun 363(3):506-12. Epub 2007 Sep 17. 2007
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| 21 | CDK4, CDK6
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| CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms.
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| Ruas M, Gregory F, Jones R, Poolman R, Starborg M, Rowe J, Brookes S, Peters G.
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| Mol Cell Biol 27(12):4273-82. Epub 2007 Apr 9. 2007
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| 22 | CDK4, JUND
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| Induced JunD in intestinal epithelial cells represses CDK4 transcription through its proximal promoter region following polyamine depletion.
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| Xiao L, Rao JN, Zou T, Liu L, Marasa BS, Chen J, Turner DJ, Passaniti A, Wang JY.
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| Biochem J 403(3):573-81.
2007
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| 23 | CDK4, CMM3
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| A large Norwegian family with inherited malignant melanoma, multiple atypical nevi, and CDK4 mutation.
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| Molven A, Grimstvedt MB, Steine SJ, Harland M, Avril MF, Hayward NK, Akslen LA.
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| Genes Chromosomes Cancer 44(1):10-8. 2005
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| 24 | PSMD10, CDK4, PSMC4
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| Gankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasome.
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| Dawson S, Apcher S, Mee M, Higashitsuji H, Baker R, Uhle S, Dubiel W, Fujita J, Mayer RJ.
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| J Biol Chem 277(13):10893-902. Epub 2002 Jan 04. 2002
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| 25 | CDK4, HMGA2, MDM2
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| Dedifferentiation of a well-differentiated liposarcoma to a highly malignant metastatic osteosarcoma: amplification of 12q14 at all stages and gain of 1q22-q24 associated with metastases.
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| Forus A, Larramendy ML, Meza-Zepeda LA, Bjerkehagen B, Godager LH, Dahlberg AB, Saeter G, Knuutila S, Myklebost O.
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| Cancer Genet Cytogenet 125(2):100-11. 2001
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| 26 | CDK4, MYC
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| Identification of CDK4 as a target of c-MYC.
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| Hermeking H, Rago C, Schuhmacher M, Li Q, Barrett JF, Obaya AJ, O'Connell BC, Mateyak MK, Tam W, Kohlhuber F, Dang CV, Sedivy JM, Eick D, Vogelstein B, Kinzler KW.
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| Proc Natl Acad Sci U S A 97(5):2229-34. 2000
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| 27 | CDK4, CDKN2A
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| CDK4 gene amplification in osteosarcoma : reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons.
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| Wei G, et al.
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| Int J Cancer 80 : 199-204. 1999
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| 28 | CDK4
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| Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation.
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| An HX, et al.
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| Am J Pathol 154(1):113-8. 1999
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| 29 | CDK4
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| Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia.
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| Rane SG, et al.
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| Nat Genet 22(1):44-52. 1999
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| 30 | CDK4, CDKN2A
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| Normal repair of ultraviolet radiation-induced DNA damage in familial melanoma without CDKN2A or CDK4 gene mutation.
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| Shannon JA, et al.
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| Melanoma Res 9(2):133-7. 1999
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| 31 | CDK4, CDKN2A, CMM3
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| Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France.
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| Soufir N, Avril MF, Chompret A, Demenais F, Bombled J, Spatz A, Stoppa-Lyonnet D, Benard J, Bressac-de Paillerets B.
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| Hum Mol Genet 7(2):209-16. 1998
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| 32 | BCL2, BCL8, BRINP1, CDK4, GLI1, MDM2, MYC, REL
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| Chromosomal and gene amplification in diffuse large B-cell lymphoma.
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| Rao PH, et al.
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| Blood 92 : 234-240. 1998
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| 33 | CDK4, CMM3
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| Complete scanning of the CDK4 gene by denaturing gradient gel electrophoresis: a novel missense mutation but low overall frequency of mutations in sporadic metastatic malignant melanoma.
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| Guldberg P, Kirkin AF, Gronbaek K, thor Straten P, Ahrenkiel V, Zeuthen J.
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| Int J Cancer 72(5):780-3. 1997
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| 34 | CDK4, CMM3
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| Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma.
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| Zuo L, et al.
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| Nat Genet 12 : 97-99. 1996
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| 35 | CDK4, MCM7
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| Shared role of the pRB-related p130 and p107 proteins in limb development.
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| Cobrinik D, et al.
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| Genes Dev 10 : 1633-1644. 1996
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| 36 | CDK4, CDKN2A, CMM2, TSG9A
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| Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma : analysis of a clinic-based population.
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| Fitzgerald MG, et al.
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| Proc Natl Acad Sci U S A 93 : 8541-8545. 1996
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| 37 | CDK4, MDM2, TSPAN31
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| Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets.
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| Reifenberger G, et al.
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| Cancer Res 56 : 5141-5145. 1996
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| 38 | CDK4, DDIT3, GLI1, MDM2
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| Mapping of gene loci in the Q13-Q15 region of chromosome 12.
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| Mitchell ELD, et al.
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| Chromosome Res 3 : 261-262. 1995
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| 39 | CDK4, CMM3
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| A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma.
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| Wšlfel T, et al.
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| Science 269 : 1281-1284. 1995
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| 40 | CDK2, CDK4, CDK5
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| Chromosomal mapping of human CDK2,CDK4, and CDK5 cell cycle kinase genes.
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| Demetrick DJ, et al.
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| Cytogenet Cell Genet 66 : 72-74. 1994
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| 41 | CDKN2A, TSG9A, CDK4
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| CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.
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| Schmidt EE, et al.
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| Cancer Res 54 : 6321-6324. 1994
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| 42 | CDK4, CDK6
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| CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.
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| Bates S, et al.
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| Oncogene 9 : 71-79. 1994
|