| Symbol
| CDK2
| contributors: mct/npt/shn/pgu - updated : 24-12-2019
|
| HGNC name
| cyclin-dependent kinase 2
|
| HGNC id
| 1771
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
| --over
|
| |
in suprabasal layers of perilesional (unaffected) skin, indicating that pemphigus vulgaris -induced changes in CDK2 levels may precede the phenotypic manifestations of disease | |
Variant & Polymorphism
| 
| |
Candidate gene
Marker
| Therapy target
| may be a suitable drug target in melanoma because of its depletion suppressing growth and cell cycle progression | |
interfering RNA depletion of Cdk2 prevented cell-cell detachment induced by pemphigus vulgaris sera ( | |
pharmacological inhibition of Cdk2 activity through roscovitine prevented blister formation and acantholysis in the mouse model of the pemphigus vulgaris disease ( | |
| | |
|
| mouse embryonic fibroblats lacking CDK2 proliferates normally and become immortal after continuous passage in culture ( | |
Cdk2-/- mice are viable and survive for up to two years ( |
|
Cdk2 loss does not affect oligodendrocyte progenitor cell cell cycle, oligodendrocyte cell numbers, or myelination during central nervous system development ( |