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FLASH GENE
Symbol GPD1 contributors: mct - updated : 25-01-2012
HGNC name glycerol-3-phosphate dehydrogenase 1 (soluble)
HGNC id 4455
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
secondary structure secondary structure with various active sites in addition to a relatively conserved C terminal
HOMOLOGY
Homologene
FAMILY
  • NAD-dependent glycerol-3-phosphate dehydrogenase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • GRB14, GPD1, and MSTN are potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle
  • key enzyme that connects carbohydrate and lipid metabolism
  • catalyzes the reversible redox reaction of dihydroxyacetone phosphate (DHAP) and nicotine adenine dinucleotide, reduced (NADH) to glycerol-3-phosphate (G3P) and nicotinamide adenine dinucleotide (NAD+)
  • with GPD2, plays an important role in the transport of reducing equivalents from the cytosol to the mitochondria
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TCHF
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    contributing to the increase of triacylglycerol (TAG) synthesis in obese subjects
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS