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FLASH GENE
Symbol PRG2 contributors: mct - updated : 23-09-2014
HGNC name proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
HGNC id 9362
DNA
TYPE functioning gene
STRUCTURE 3.30 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
alternative promoter
Binding site
text structure two alternative promoters P& and Pé
  • binding sites for CEBPE,GATA1,SPI1
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 874 25.2 222 - Li (1995)
    - splicing 1630 25.2 222 higher in immature cells Li (1995)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticeosinophil
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • lectin C type domain, 15AA hydrophobic signal sequence
    • isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • plasticity-related gene family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • mediator of injury to parasites and tissues in allergy inflammation
  • brain-specific integral membrane protein implicated in neuronal plasticity, such as filopodia formation and axon growth after brain lesion (Broggini 2010)
  • phospholipid-interacting molecule, important for thalamocortical axon guidance
  • bioactive phospholipids and PRG2 are critical for guiding thalamic axons to their proper cortical targets
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • detaches surface-bound PAPPA in a process that depends on the PRG2 GAG and also on the formation of intermolecular disulfide bonds between PAPPA and PRG2
  • RDX is a PRG2 interaction partner and radixin accumulation in growth cones and its LPA-dependent phosphorylation depend on its binding to specific regions within the C-terminal region of PRG2
    • cell & other
    REGULATION
    Other synergistically transactivated by GATA1 and SPI (PU-1) in the cotext of optimal level of GATA1
    GATA1 PU1 synergy abolished and PRG2 repressed by CEBPespilon special isoform
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS