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FLASH GENE
Symbol GOT2 contributors: mct - updated : 08-10-2019
HGNC name glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
HGNC id 4433
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,mitochondria,matrix
basic FUNCTION
  • plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles
  • GOT2 acetylation stimulates the malate-aspartate NADH shuttle activity and oxidative protection
  • essentiality of GOT2 in senescence regulation of pancreatic ductal adenocarcinoma (PDAC), which is dispensable in their normal counterparts, may have profound implications for the development of strategies to treat these refractory cancers
  • encodes the mitochondrial glutamate oxaloacetate transaminase
  • GOT1, GOT2 catalyze the reversible interconversion of oxaloacetate and glutamate into aspartate and alpha-ketoglutarate
  • member of the malate-aspartate shuttle, playing an essential role in the intracellular NAD(H) redox balance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mitochondrial GOT2 is acetylated and deacetylation depends on mitochondrial SIRT3
  • BRCA1 modulates aspartate biosynthesis through transcriptional repression of GOT2, providing a biological basis for treatment choices in breast cancer
  • HIF1A acts as a direct repressor of aspartate biosynthesis involving the suppression of several key aspartate-producing proteins, including cytosolic GOT1 and mitochondrial GOT2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE82
    related resource MITOP database
    Susceptibility
  • to cardiovascular disease and metabolic syndrome (MetS)
    • Variant & Polymorphism SNP
  • rs6993 located in the 3 prime untranslated region of the GOT2 locus was significantly associated with features of the MetS, including arterial hypertension
    • Candidate gene
    Marker
  • can serve as an independent prognostic factor for overall survival and disease-free survival of patients with breast cancer, especially triple-negative breast cancer
    • Therapy target
    ANIMAL & CELL MODELS