| 1 | EIEE82, GOT1, GOT2
|
| Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy.
|
| van Karnebeek CDM, Ramos RJ, Wen XY, Tarailo-Graovac M, Gleeson JG, Skrypnyk C, Brand-Arzamendi K, Karbassi F, Issa MY, van der Lee R, Drögemöller BI, Koster J, Rousseau J, Campeau PM, Wang Y, Cao F, Li M, Ruiter J, Ciapaite J, Kluijtmans LAJ, Willemsen MAAP, Jans JJ, Ross CJ, Wintjes LT, Rodenburg RJ, Huigen MCDG, Jia Z, Waterham HR, Wasserman WW, Wanders RJA, Verhoeven-Duif NM, Zaki MS, Wevers RA.
|
| Am J Hum Genet 105(3):534-548. doi: 10.1016/j.ajhg.2019.07.015. Epub 2019 Aug 15. 2019
|
| 2 | GOT1, GOT2, HIF1A
|
| HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis.
|
| Meléndez-Rodríguez F, Urrutia AA, Lorendeau D, Rinaldi G, Roche O, Böğürcü-Seidel N, Ortega Muelas M, Mesa-Ciller C, Turiel G, Bouthelier A, Hernansanz-Agustín P, Elorza A, Escasany E, Li QOY, Torres-Capelli M, Tello D, Fuertes E, Fraga E, Martínez-Ruiz A, Pérez B, Giménez-Bachs JM, Salinas-Sánchez AS, Acker T, Sánchez Prieto R, Fendt SM, De Bock K, Aragonés J.
|
| Cell Rep 26(9):2257-2265.e4. doi: 10.1016/j.celrep.2019.01.106.
2019
|
| 3 | BRCA1, GOT1, GOT2
|
| Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation.
|
| Hong R, Zhang W, Xia X, Zhang K, Wang Y, Wu M, Fan J, Li J, Xia W, Xu F, Chen J, Wang S, Zhan Q.
|
| Mol Oncol 13(4):959-977. doi: 10.1002/1878-0261.12466. Epub 2019 Mar 1.
2019
|
| 4 | GOT2
|
| Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition.
|
| Yang S, Hwang S, Kim M, Seo SB, Lee JH, Jeong SM.
|
| Cell Death Dis 9(2):55. doi: 10.1038/s41419-017-0089-1.
2018
|
| 5 | GOT2
|
| Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level.
|
| Sookoian S, Castaño GO, Scian R, Fernández Gianotti T, Dopazo H, Rohr C, Gaj G, San Martino J, Sevic I, Flichman D, Pirola CJ.
|
| Am J Clin Nutr 103(2):422-34. doi: 10.3945/ajcn.115.118695. Epub 2016 Jan 20.
2016
|
| 6 | GOT2, SIRT3
|
| SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth.
|
| Yang H, Zhou L, Shi Q, Zhao Y, Lin H, Zhang M, Zhao S, Yang Y, Ling ZQ, Guan KL, Xiong Y, Ye D.
|
| EMBO J 34(8):1110-25. doi: 10.15252/embj.201591041. Epub 2015 Mar 9.
2015
|
| 7 | GOT2
|
| Acute mitochondrial dysfunction after blast exposure: potential role of mitochondrial glutamate oxaloacetate transaminase.
|
| Arun P, Abu-Taleb R, Oguntayo S, Wang Y, Valiyaveettil M, Long JB, Nambiar MP.
|
| J Neurotrauma 30(19):1645-51. doi: 10.1089/neu.2012.2834. Epub 2013 Aug 9.
2013
|
| 8 | GOT2
|
| Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV.
|
| Han Q, Robinson H, Cai T, Tagle DA, Li J.
|
| Biosci Rep 31(5):323-32. doi: 10.1042/BSR20100117.
2011
|
| 9 | GOT2
|
| Immunogold localization of mitochondrial aspartate aminotransferase in mitochondria and on the cell surface in normal rat tissues.
|
| Cechetto JD, Sadacharan SK, Berk PD, Gupta RS.
|
| Histol Histopathol 17(2):353-64. doi: 10.14670/HH-17.353.
2002
|
| 10 | GOT1, GOT2, GOT2P1, GOT2P2, GOT2P3
|
| Chromosomal localization of human aspartate aminotransferase genes by in situ hybridization.
|
| Pol S, et al.
|
| Hum Genet 83 : 159-164. 1989
|
| 11 | GOT2
|
| Mapping studies on human mitochondrial glutamate oxaloacetate transaminase.
|
| Jeremiah SJ, Povey S, Burley MW, Kielty C, Lee M, Spowart G, Corney G, Cook PJ.
|
| Ann Hum Genet 46 : 145-152. 1982
|
| 12 | GOT2
|
| Assignment to chromosome 16 of a gene necessary for the expression of human mitochondrial glutamate oxaloacetate transaminase (aspartate aminotransferase) (E.C.2.6.1.1).
|
| Tolley E, et al.
|
| Biochem Genet 18 : 947-954. 1980
|