Citations for
1EIEE82, GOT1, GOT2
Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy.
van Karnebeek CDM, Ramos RJ, Wen XY, Tarailo-Graovac M, Gleeson JG, Skrypnyk C, Brand-Arzamendi K, Karbassi F, Issa MY, van der Lee R, Drögemöller BI, Koster J, Rousseau J, Campeau PM, Wang Y, Cao F, Li M, Ruiter J, Ciapaite J, Kluijtmans LAJ, Willemsen MAAP, Jans JJ, Ross CJ, Wintjes LT, Rodenburg RJ, Huigen MCDG, Jia Z, Waterham HR, Wasserman WW, Wanders RJA, Verhoeven-Duif NM, Zaki MS, Wevers RA.
Am J Hum Genet 105(3):534-548. doi: 10.1016/j.ajhg.2019.07.015. Epub 2019 Aug 15. 2019
2GOT1, GOT2, HIF1A
HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis.
Meléndez-Rodríguez F, Urrutia AA, Lorendeau D, Rinaldi G, Roche O, Böğürcü-Seidel N, Ortega Muelas M, Mesa-Ciller C, Turiel G, Bouthelier A, Hernansanz-Agustín P, Elorza A, Escasany E, Li QOY, Torres-Capelli M, Tello D, Fuertes E, Fraga E, Martínez-Ruiz A, Pérez B, Giménez-Bachs JM, Salinas-Sánchez AS, Acker T, Sánchez Prieto R, Fendt SM, De Bock K, Aragonés J.
Cell Rep 26(9):2257-2265.e4. doi: 10.1016/j.celrep.2019.01.106. 2019
3BRCA1, GOT1, GOT2
Preventing BRCA1/ZBRK1 repressor complex binding to the GOT2 promoter results in accelerated aspartate biosynthesis and promotion of cell proliferation.
Hong R, Zhang W, Xia X, Zhang K, Wang Y, Wu M, Fan J, Li J, Xia W, Xu F, Chen J, Wang S, Zhan Q.
Mol Oncol 13(4):959-977. doi: 10.1002/1878-0261.12466. Epub 2019 Mar 1. 2019
4GOT2
Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition.
Yang S, Hwang S, Kim M, Seo SB, Lee JH, Jeong SM.
Cell Death Dis 9(2):55. doi: 10.1038/s41419-017-0089-1. 2018
5GOT2
Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level.
Sookoian S, Castańo GO, Scian R, Fernández Gianotti T, Dopazo H, Rohr C, Gaj G, San Martino J, Sevic I, Flichman D, Pirola CJ.
Am J Clin Nutr 103(2):422-34. doi: 10.3945/ajcn.115.118695. Epub 2016 Jan 20. 2016
6GOT2, SIRT3
SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth.
Yang H, Zhou L, Shi Q, Zhao Y, Lin H, Zhang M, Zhao S, Yang Y, Ling ZQ, Guan KL, Xiong Y, Ye D.
EMBO J 34(8):1110-25. doi: 10.15252/embj.201591041. Epub 2015 Mar 9. 2015
7GOT2
Acute mitochondrial dysfunction after blast exposure: potential role of mitochondrial glutamate oxaloacetate transaminase.
Arun P, Abu-Taleb R, Oguntayo S, Wang Y, Valiyaveettil M, Long JB, Nambiar MP.
J Neurotrauma 30(19):1645-51. doi: 10.1089/neu.2012.2834. Epub 2013 Aug 9. 2013
8GOT2
Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV.
Han Q, Robinson H, Cai T, Tagle DA, Li J.
Biosci Rep 31(5):323-32. doi: 10.1042/BSR20100117. 2011
9GOT2
Immunogold localization of mitochondrial aspartate aminotransferase in mitochondria and on the cell surface in normal rat tissues.
Cechetto JD, Sadacharan SK, Berk PD, Gupta RS.
Histol Histopathol 17(2):353-64. doi: 10.14670/HH-17.353. 2002
10GOT1, GOT2, GOT2P1, GOT2P2, GOT2P3
Chromosomal localization of human aspartate aminotransferase genes by in situ hybridization.
Pol S, et al.
Hum Genet 83 : 159-164. 1989
11GOT2
Mapping studies on human mitochondrial glutamate oxaloacetate transaminase.
Jeremiah SJ, Povey S, Burley MW, Kielty C, Lee M, Spowart G, Corney G, Cook PJ.
Ann Hum Genet 46 : 145-152. 1982
12GOT2
Assignment to chromosome 16 of a gene necessary for the expression of human mitochondrial glutamate oxaloacetate transaminase (aspartate aminotransferase) (E.C.2.6.1.1).
Tolley E, et al.
Biochem Genet 18 : 947-954. 1980