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FLASH GENE
Symbol GOT2 contributors: mct - updated : 08-10-2019
HGNC name glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
HGNC id 4433
Corresponding disease
EIEE82 epileptic encephalopathy, early infantile, 82
Location 16q21      Physical location : 58.741.034 - 58.768.246
Synonym name
  • aspartate aminotransferase 2
  • kynurenine aminotransferase 4
  • kynurenine--oxoglutarate transaminase 4
  • kynurenine--oxoglutarate transaminase IV
  • mAspAT
  • plasma membrane-associated fatty acid-binding protein
    • Synonym symbol(s) MDAT1, FLJ40994, KAT4, KATIV, KYAT4, mitAAT
    EC.number 2.6.1.1/2.6.1.7
    DNA
    TYPE functioning gene
    STRUCTURE 27.19 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2292 - 387 - 2015 25755250
    10 - 2421 - 430 - 2015 25755250
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivemouthtongue  highly
    Lymphoid/Immunespleen   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles
  • GOT2 acetylation stimulates the malate-aspartate NADH shuttle activity and oxidative protection
  • essentiality of GOT2 in senescence regulation of pancreatic ductal adenocarcinoma (PDAC), which is dispensable in their normal counterparts, may have profound implications for the development of strategies to treat these refractory cancers
  • encodes the mitochondrial glutamate oxaloacetate transaminase
  • GOT1, GOT2 catalyze the reversible interconversion of oxaloacetate and glutamate into aspartate and alpha-ketoglutarate
  • member of the malate-aspartate shuttle, playing an essential role in the intracellular NAD(H) redox balance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mitochondrial GOT2 is acetylated and deacetylation depends on mitochondrial SIRT3
  • BRCA1 modulates aspartate biosynthesis through transcriptional repression of GOT2, providing a biological basis for treatment choices in breast cancer
  • HIF1A acts as a direct repressor of aspartate biosynthesis involving the suppression of several key aspartate-producing proteins, including cytosolic GOT1 and mitochondrial GOT2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE82
    related resource MITOP database
    Susceptibility
  • to cardiovascular disease and metabolic syndrome (MetS)
    • Variant & Polymorphism SNP
  • rs6993 located in the 3 prime untranslated region of the GOT2 locus was significantly associated with features of the MetS, including arterial hypertension
    • Candidate gene
    Marker
  • can serve as an independent prognostic factor for overall survival and disease-free survival of patients with breast cancer, especially triple-negative breast cancer
    • Therapy target
    ANIMAL & CELL MODELS