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FLASH GENE
Symbol IGFALS contributors: mct/npt - updated : 26-01-2010
HGNC name insulin-like growth factor binding protein, acid labile subunit
HGNC id 5468
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • 27 AA hydrophobic sequence (18 to 20 leucine-rich repeats of 24 AA)
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Igfals
    homolog to murine Igfals
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion
  • having a key role in regulating transendothelial IGF transport, but other factors are also involved (Payet 2004)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • key component of the 150-kD IGF circulating ternary complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ALSD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS